2,6-Dichloropyridine-3,4-diamine

Base Information

• Chemical Name: 2,6-Dichloropyridine-3,4-diamine
• CAS No.: 101079-63-4
• Molecular Formula: C5H5Cl2N3
• Molecular Weight: 178.021
• Hs Code.: 2933399090
• European Community (EC) Number: 877-741-9
• DSSTox Substance ID: DTXSID20448748
• Wikidata: Q82267881
• Mol file: 101079-63-4.mol

Synonyms:2,6-dichloropyridine-3,4-diamine;101079-63-4;3,4-Diamino-2,6-dichloropyridine;3,4-Pyridinediamine, 2,6-dichloro-;2,6-DICHLORO-3,4-PYRIDINEDIAMINE;MFCD10697689;2,6-Dichloro-pyridine-3,4-diamine;SCHEMBL259983;DTXSID20448748;HDNVWGXGFBVDKV-UHFFFAOYSA-N;AMY10238;AKOS006302729;AB60249;CS-W018981;AC-26554;DS-11867;SY007394;FT-0650401;EN300-120405;A897245;W-203179;(+)-(1S,3R)-N-Fmoc-3-aminocyclopentanecarboxylicacid;2,6-Dichloropyridine-3,4-diamine

Chemical Property of 2,6-Dichloropyridine-3,4-diamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 181-183℃
• Refractive Index: 1.693
• Boiling Point: 424.014 °C at 760 mmHg
• PKA: 0.50±0.50(Predicted)
• Flash Point: 210.236 °C
• PSA: 64.93000
• Density: 1.602 g/cm³
• LogP: 2.71520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 176.9860526
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloropyridine-3,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(N=C1Cl)Cl)N)N

Technology Process of 2,6-Dichloropyridine-3,4-diamine

There total 8 articles about 2,6-Dichloropyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dichloro-3-nitropyridin-4-amine (2897-43-0) → 3,4-diamino-2,6-dichloropyridine (101079-63-4)

Guidance literature:

With hydrogen; In methanol; for 4h;

DOI:10.1021/ml500352s

Reference yield:

2,6-dichloro-[4]pyridylamine (2587-02-2) → 3,4-diamino-2,6-dichloropyridine (101079-63-4)

Guidance literature:

Multi-step reaction with 4 steps

1: HNO₃; H₂SO₄ / 20 °C

2: H₂SO₄ / 100 °C

3: 51 percent / Fe / 2 h / Heating

4: aq. NaOH / Heating

With sodium hydroxide; sulfuric acid; nitric acid; iron;

DOI:10.1081/NCN-120026635

Reference yield:

2,6-dichloro-N-nitro-4-pyridinamine (2587-03-3) → 3,4-diamino-2,6-dichloropyridine (101079-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / 100 °C

2: 51 percent / Fe / 2 h / Heating

3: aq. NaOH / Heating

With sodium hydroxide; sulfuric acid; iron;

DOI:10.1081/NCN-120026635

upstream raw materials:

2,6-dichloro-3-nitropyridin-4-amine

3-amino-4-acetamido-2,6-dichloropyridine

2,6-dichloropyridine

2,6-dichloro-[4]pyridylamine

Downstream raw materials:

4,6-dichloro-1H-imidazo<4,5-c>pyridine

8-chloro-3-deazaadenine

3-chloro-3-deazaadenine

2,6-dichloro-8-oxo-3-deazaadenine