2H-1,2,4-Triazole-3-carboxamide

Base Information

• Chemical Name: 2H-1,2,4-Triazole-3-carboxamide
• CAS No.: 3641-08-5
• Molecular Formula: C3H4N4O
• Molecular Weight: 112.091
• Hs Code.: 2933999552
• Mol file: 3641-08-5.mol

Synonyms:1H-1,2,4-Triazole-3-carboxamide(9CI);s-Triazole-3-carboxamide (7CI,8CI);1H-1,2,4-Triazole-5-carboxamide;NSC80860;

Chemical Property of 2H-1,2,4-Triazole-3-carboxamide

Chemical Property:

• Vapor Pressure: 2.14E-06mmHg at 25°C
• Melting Point: 315 °C
• Refractive Index: 1.625
• Boiling Point: 393.4 °C at 760 mmHg
• PKA: 8.50±0.20(Predicted)
• Flash Point: 191.7 °C
• PSA: 84.66000
• Density: 1.537 g/cm³
• LogP: -0.39610
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Des-1-β-D-ribofuranosylRibavirin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Technology Process of 2H-1,2,4-Triazole-3-carboxamide

There total 9 articles about 2H-1,2,4-Triazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.2%

oxalamic acid hydrazide (515-96-8) + ethyl formimidate hydrochloride (16694-46-5) → 1,2,4-triazole-3-carboxamide (3641-08-5)

Guidance literature:

ethyl formimidate hydrochloride; With sodium ethanolate; formamide; at 20 ℃; for 0.166667h;

oxalamic acid hydrazide; at 130 ℃; for 10h; under 75007.5 Torr; Reagent/catalyst;

Reference yield: 70.0%

C5H9N3O2 → 1,2,4-triazole-3-carboxamide (3641-08-5)

Guidance literature:

With hydrazine hydrochloride; acetic acid; In i-Amyl alcohol; at 130 ℃; for 10h; Reagent/catalyst; Temperature; Solvent;

Reference yield: 37.0%

methyl 1H-1,2,4-triazole-3-carboxylate (4928-88-5) → 1,2,4-triazole-3-carboxamide (3641-08-5)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 48h;

DOI:10.1021/ol7016802

upstream raw materials:

methyl 1H-1,2,4-triazole-3-carboxylate

ribavirin

oxalamic acid hydrazide

ethyl formimidate hydrochloride

Downstream raw materials:

ribavirin

1-(β-D-Arabinofuranosyl)-<1,2,4>triazol-3-carboxamid

1-(2'-deoxy-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide

methyl 1H-1,2,4-triazole-3-carboxylate

Refernces

• 1、 Wu, Jim Zhen,Larson, Gary,Hong, Zhi. "Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin". . p. 4006 - 4008. Retrieved 2004.
• 2、 -. "Synthetic method of 1,2,4-triazole-3-formamide". Page/Page column 4-6. . Retrieved 2018/12/05.
• 3、 Konstantinova,Chudinov,Fateev,Matveev,Zhurilo,Shvets,Miroshnikov. "Chemoenzymatic method of 1,2,4-triazole nucleoside synthesis: Possibilities and limitations". . p. 53 - 71. Retrieved 2013/04/10.