515-96-8Relevant academic research and scientific papers
PHENYLALKYL OXAMIDES
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, (2008/06/13)
Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefor useful in the treatment of disease states mediated or exacerbated thereby
Antihypertensive actions of hydrazidones: Study of acylated dichloroarylhydrazones
Cave,Galons,Miocque,Rinjard,Tran,Binet
, p. 75 - 79 (2007/10/02)
A series of acylated dichloroarylhydrazones has been prepared and evaluated on spontaneously hypertensive rats (SHR). The presence of 2-Cl and 6-Cl aromatic substituents in a clonidine like position is not required since derivatives bearing 2- and 4-chloro as well as 3- and 4-chloro substituents exert antihypertensive activities. Activity is also maintained in certain 2,6 disubstituted derivatives where one of the chlorine atoms is replaced by F or NO2.
