2-Pyridinecarboxylic acid, 4-[2-[[(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]- 2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]-, methyl ester

Base Information

Chemical Name:2-Pyridinecarboxylic acid, 4-[2-[[(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]- 2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]-, methyl ester
CAS No.:502509-31-1
Molecular Formula:C₃₉H₄₈N₄O₃
Molecular Weight:620.835
Hs Code.:

2-Pyridinecarboxylic acid,
4-[2-[[(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]-
2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]-, methyl ester

Synonyms:

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Chemical Property of 2-Pyridinecarboxylic acid, 4-[2-[[(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]- 2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]-, methyl ester

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Technology Process of 2-Pyridinecarboxylic acid, 4-[2-[[(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]- 2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]-, methyl ester

There total 7 articles about 2-Pyridinecarboxylic acid, 4-[2-[[(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]- 2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{2-[{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propyl}-(2,4-dinitro-benzenesulfonyl)-amino]-ethyl}-pyridine-2-carboxylic acid methyl ester

: 502509-31-1
4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: With propylamine; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1016/S0960-894X(02)00751-5

Reference yield:

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 502509-31-1
4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 2,6-lutidine / CH₂Cl₂ / 0.17 h / 0 °C

2: aq. H₂O₂; MeReO₃ / CH₂Cl₂ / 1 h / 20 °C

3: dimethylcarbamoyl chloride / CH₂Cl₂ / 23 h / 20 °C

4: 6 N aq. HCl / 24 h / Heating

5: H₂SO₄ / 16 h / Heating

6: PPh₃; DEAD / CH₂Cl₂ / 3 h / 20 °C

7: n-PrNH₂ / CH₂Cl₂ / 0.33 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; propylamine; sulfuric acid; dihydrogen peroxide; methyltrioxorhenium(VII); triphenylphosphine; N,N-Dimethylcarbamoyl chloride; diethylazodicarboxylate; In dichloromethane; 3: Reissert reaction / 6: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00751-5

Reference yield:

: 117423-31-1
4-(2-((t-butyldimethylsilyl)oxy)ethyl)picolinonitrile

: 502509-31-1
4-(2-{2-[5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propylamino}-ethyl)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 6 N aq. HCl / 24 h / Heating

2: H₂SO₄ / 16 h / Heating

3: PPh₃; DEAD / CH₂Cl₂ / 3 h / 20 °C

4: n-PrNH₂ / CH₂Cl₂ / 0.33 h / 20 °C

With hydrogenchloride; propylamine; sulfuric acid; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; 3: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00751-5