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5344-27-4 Usage


4-Pyridineethanol, also known as 4-(2-Hydroxyethyl)pyridine, is an organic compound with the molecular formula C7H9NO. It features a pyridine ring with an ethanol group attached to the 4th position. 4-Pyridineethanol is known for its reactivity and is commonly used in the synthesis of various pharmaceuticals and organic compounds.


Used in Organic Synthesis:
4-Pyridineethanol is used as a reagent for the protection of carboxyl groups in organic synthesis. It forms 2-(4-pyridyl)ethyl esters, which are crucial for protecting the carboxyl functionality during chemical reactions, preventing unwanted side reactions, and facilitating the selective functionalization of other groups in the molecule.
Used in Pharmaceutical Industry:
4-Pyridineethanol serves as an intermediate in the synthesis of active pharmaceutical ingredients. Its unique structure allows it to be a versatile building block for the development of new drugs with potential applications in various therapeutic areas. 4-Pyridineethanol's ability to form esters with carboxyl groups makes it particularly useful in the design and synthesis of novel drug candidates.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 5344-27-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,4 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5344-27:
84 % 10 = 4
So 5344-27-4 is a valid CAS Registry Number.

5344-27-4 Well-known Company Product Price

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  • Alfa Aesar

  • (L13780)  4-(2-Hydroxyethyl)pyridine, 98%   

  • 5344-27-4

  • 1g

  • 646.0CNY

  • Detail
  • Alfa Aesar

  • (L13780)  4-(2-Hydroxyethyl)pyridine, 98%   

  • 5344-27-4

  • 5g

  • 2306.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 2-(Pyridin-4-yl)ethanol

1.2 Other means of identification

Product number -
Other names 4-(2-Hydroxyethyl)pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5344-27-4 SDS

5344-27-4Relevant articles and documents

Radical Hydroarylation of Functionalized Olefins and Mechanistic Investigation of Photocatalytic Pyridyl Radical Reactions

Seath, Ciaran P.,Vogt, David B.,Xu, Zihao,Boyington, Allyson J.,Jui, Nathan T.

, p. 15525 - 15534 (2018/11/23)

We report the photoredox alkylation of halopyridines using functionalized alkene and alkyne building blocks. Selective single-electron reduction of the halogenated pyridines provides the corresponding heteroaryl radicals, which undergo anti-Markovnikov addition to the alkene substrates. The system is shown to be mild and tolerant of a variety of alkene and alkyne subtypes. A combination of computational and experimental studies support a mechanism involving proton-coupled electron transfer followed by medium-dependent alkene addition and rapid hydrogen atom transfer mediated by a polarity-reversal catalyst.

Nucleophilic addition of arylmethylzinc reagents (ArCH2ZnCl) to formaldehyde: An easy access to 2-(hetro)arylethyl alcohols

Bhatt,Samant,Pednekar, Suhas

supporting information, p. 968 - 974 (2017/05/04)

The selective addition of arylmethylmagnesium halides with formaldehyde giving arylethyl alcohols is extremely challenging. To circumvent the difficulties, in the current communication, we have reported on the nucleophilic addition of benzyl zinc reagents derived from inexpensive and abundant benzyl chlorides to paraformaldehyde. The reaction investigated herein is hitherto unknown and was found to be selective, operationally simple, atom- and step-economical and high yielding to deliver phenethyl alcohols utilized as key perfumery ingredients in 60–83% yields. After successful establishment of the reaction condition, the reaction was also scaled up successfully to deliver a large-scale preparation of the phenethyl alcohol.

Tetrazole excitatory amino acid receptor antagonists


, (2008/06/13)

The present invention provides novel tetrazole derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.

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