2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)-
CAS No.:503068-36-8
Molecular Formula:C28H35Cl2NO6
Molecular Weight:552.495
Hs Code.:
Mol file:503068-36-8.mol

Synonyms:(5R)-3-{6-[2-(2,6-dichlorobenzyloxy)ethoxy]hexyl}-5-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)oxazolidin-2-one;2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]-5-(2,2-dimethyl-4h-1, 3-benzodioxin-6-yl)-, (5r)-;

Suppliers and Price of 2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
(R)-3-[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]-5-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)oxazolidin-2-one
10mg
$ 1260.00

Total 39 raw suppliers

Chemical Property of 2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)-

Chemical Property:

Boiling Point:691.1±55.0 °C(Predicted)
PKA:-1.88±0.40(Predicted)
PSA：66.46000
Density:1.229±0.06 g/cm3(Predicted)
LogP:6.86350

Purity/Quality:

99%, ^*data from raw suppliers

(R)-3-[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]-5-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)oxazolidin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (R)-3-[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]-5-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)oxazolidin-2-one is an intermediate in the preparation of Vilanterol Trifenatate (V260000), a long-acting β2 adrenergic receptor agonist.

Technology Process of 2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)-

There total 12 articles about 2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 503070-57-3
2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene

: 452339-73-0
(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

: 503068-36-8
(5R)-3-{6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

Guidance literature:: (5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 15258-73-8
2,6-dichlorobenzyl alcohol

: 503068-55-1
2-({6-[(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxo-1,3-oxazolidin-3-yl]hexyl}oxy)ethyl methanesulfonate

: 503068-36-8
(5R)-3-{6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

Guidance literature:: 2,6-dichlorobenzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

2-({6-[(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxo-1,3-oxazolidin-3-yl]hexyl}oxy)ethyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1021/jm100326d

Reference yield:

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 503068-36-8
(5R)-3-{6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 1 h / 35 - 45 °C / Inert atmosphere

1.2: 1 h / 40 - 60 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 20 h / 55 - 60 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With potassium tert-butylate; tetrabutylammomium bromide; sodium hydroxide; In water; N,N-dimethyl-formamide; toluene;