Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro

Base Information

• Chemical Name: Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro
• CAS No.: 503070-57-3
• Molecular Formula: C15H21BrCl2O2
• Molecular Weight: 384.13600
• Mol file: 503070-57-3.mol

Synonyms:

Chemical Property of Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro

Chemical Property:

• Boiling Point: 420.8±45.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.335±0.06 g/cm3(Predicted)
• LogP: 5.48190
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene is an intermediate in the synthesis of Vilanterol Trifenatate-d4 (V260002). Vilanterol Trifenatate (V260000) is a long-acting β2 adrenergic receptor Agonist. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.

Technology Process of Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro

There total 4 articles about Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1 ,6-dibromohexane (629-03-8) + 2-(2,6-dichlorobenzyloxy)ethanol → 2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene (503070-57-3)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 55 - 60 ℃; for 20h;

Reference yield:

2,6-Dichlorobenzyl bromide (20443-98-5) → 2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene (503070-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1 h / 35 - 45 °C / Inert atmosphere

1.2: 1 h / 40 - 60 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 20 h / 55 - 60 °C

With potassium tert-butylate; tetrabutylammomium bromide; sodium hydroxide; In water; toluene;

Reference yield:

1,3-Dichloro-2-chloromethyl-benzene (2014-83-7) → 2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene (503070-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1 h / 80 °C / Inert atmosphere

2: sodium hydroxide; tetrabutylammomium bromide / water / 16 h / 20 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium hydroxide; In water;

upstream raw materials:

2,6-Dichlorobenzyl bromide

1 ,6-dibromohexane

1,3-Dichloro-2-chloromethyl-benzene

2,6-dichlorobenzyl alcohol

Downstream raw materials:

(2R)-hydroxy-2-(2,2-dimethyl-4Η-1,3-benzodioxole-6-yl)-N-3-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]-ethylamine

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