1-Propanone, 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-

Base Information

• Chemical Name: 1-Propanone, 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-
• CAS No.: 50470-25-2
• Molecular Formula: C9H7F3O3
• Molecular Weight: 220.148
• DSSTox Substance ID: DTXSID80449276
• Nikkaji Number: J793.726A
• Wikidata: Q82268694
• Mol file: 50470-25-2.mol

Synonyms:3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-1-propanone;333-TDPP

Chemical Property of 1-Propanone, 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 220.03472857
• Heavy Atom Count: 15
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C(C(F)(F)F)(O)O

Technology Process of 1-Propanone, 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-

There total 3 articles about 1-Propanone, 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,3,3-tetrafluoro-2-trimethylsiloxypropiophenone (1105107-53-6) → 3,3,3-trifluoro-1-phenyl-1,2-propanedione hydrate (50470-25-2)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1016/j.jfluchem.2007.12.003

Reference yield:

3-phenyl-1,1,1-trifluoropropane-2,3-dione 3-dimethylhydrazone (111269-36-4) → 3,3,3-trifluoro-1-phenyl-1,2-propanedione hydrate (50470-25-2)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.3987/COM-98-8301

Reference yield:

→ 3,3,3-trifluoro-1-phenyl-1,2-propanedione hydrate (50470-25-2)

Guidance literature:

H5C6-CH2-CO-CF3 1. SeO2 in HOAc 2. H2O;

DOI:10.1002/jhet.5570100502

upstream raw materials:

3-phenyl-1,1,1-trifluoropropane-2,3-dione 3-dimethylhydrazone

2,3,3,3-tetrafluoro-2-trimethylsiloxypropiophenone

Downstream raw materials:

1,1,1-trifluoro-3-hydrazono-3-phenyl-propan-2-one

3,3,3-trifluoro-1-phenyl-propane-1,2-dione 1-oxime

4-trifluoromethyl-6,8-dimethyl-3-phenyl-5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine-5,7-dione

4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione