4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione

Base Information

• Chemical Name: 4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione
• CAS No.: 914081-04-2
• Molecular Formula: C₁₅H₁₃F₃N₄O₃
• Molecular Weight: 354.288
• Mol file: 914081-04-2.mol

Synonyms:4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione

Chemical Property of 4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione

There total 1 articles about 4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

6-hydrazino-1,3-dimethyl-1H-pyrimidine-2,4-dione (123506-40-1) + 3,3,3-trifluoro-1-phenyl-1,2-propanedione hydrate (50470-25-2) → 4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione (914081-04-2)

Guidance literature:

In ethanol; for 12h; Heating;

DOI:10.3987/COM-06-10781

Reference yield: 74.0%

4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione (914081-04-2) → 4-trifluoromethyl-6,8-dimethyl-3-phenyl-5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine-5,7-dione (914080-99-2)

Guidance literature:

With acetic anhydride; In toluene; for 10h; Heating;

DOI:10.3987/COM-06-10781

Reference yield:

4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione (914081-04-2) → 4-trifluoromethyl-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione (914081-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Ac₂O / toluene / 10 h / Heating

2: 79 percent / NaBH₄ / ethanol / 1.5 h / 20 °C

With sodium tetrahydroborate; acetic anhydride; In ethanol; toluene;

DOI:10.3987/COM-06-10781

upstream raw materials:

6-hydrazino-1,3-dimethyl-1H-pyrimidine-2,4-dione

3,3,3-trifluoro-1-phenyl-1,2-propanedione hydrate

Downstream raw materials:

4-trifluoromethyl-6,8-dimethyl-3-phenyl-5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine-5,7-dione

4-trifluoromethyl-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione