2',3,4-Trihydroxychalcone

Base Information

Chemical Name:2',3,4-Trihydroxychalcone
CAS No.:6272-43-1
Molecular Formula:C15H12 O4
Molecular Weight:256.258
Hs Code.:2914500090
UNII:K2054N324R
Nikkaji Number:J522.540J
Wikidata:Q27891483
Pharos Ligand ID:2TUDBRW9G6D1
Metabolomics Workbench ID:26673
ChEMBL ID:CHEMBL339587
Mol file:6272-43-1.mol

Synonyms:2',3,4-trihydroxychalcone

Suppliers and Price of 2',3,4-Trihydroxychalcone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
2',3,4-Trihydroxychalcone
500 mg
$ 187.50

Biosynth Carbosynth
2',3,4-Trihydroxychalcone
250 mg
$ 118.75

Biosynth Carbosynth
2',3,4-Trihydroxychalcone
100 mg
$ 75.00

American Custom Chemicals Corporation
3-(3,4-DIHYDROXYPHENYL)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE 95.00%
5MG
$ 505.37

Total 5 raw suppliers

Chemical Property of 2',3,4-Trihydroxychalcone

Chemical Property:

Vapor Pressure:1.2E-10mmHg at 25°C
Boiling Point:500.7°C at 760 mmHg
Flash Point:270.7°C
PSA：77.76000
Density:1.384g/cm³
LogP:2.69950
XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:256.07355886
Heavy Atom Count:19
Complexity:339

Purity/Quality:: 2',3,4-Trihydroxychalcone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)C=CC2=CC(=C(C=C2)O)O)O
Isomeric SMILES:C1=CC=C(C(=C1)C(=O)/C=C/C2=CC(=C(C=C2)O)O)O

Technology Process of 2',3,4-Trihydroxychalcone

There total 3 articles about 2',3,4-Trihydroxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 139-85-5
3,4-dihydroxybenzaldehyde

: 6272-43-1
2',3'',4''-trihydroxychalcone

Guidance literature:: o-hydroxyacetophenone; With potassium hydroxide; In ethanol; water; at 20 ℃; for 0.166667h;

3,4-dihydroxybenzaldehyde; In ethanol; water; at 85 ℃; for 2h;
DOI:10.1016/j.bioorg.2019.03.054

Reference yield: 21.0%

: 79140-20-8,19152-36-4
2'-hydroxy-3,4-dimethoxychalcone

: 6272-43-1
2',3'',4''-trihydroxychalcone

: 6563-37-7
3',4'-dihydroxyflavanone

: 6344-21-4
3',4'-dimethoxyflavanone

Guidance literature:: With Aspergillus niger LSPN₀₀₁; In ethanol; at 20 ℃; for 120h; Enzymatic reaction;
DOI:10.3109/10242422.2013.813489

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 6272-43-1
2',3'',4''-trihydroxychalcone

: 6563-37-7
3',4'-dihydroxyflavanone

: 6344-21-4
3',4'-dimethoxyflavanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 12 h / 0 - 20 °C

1.2: pH 3 - 4 / Cooling with ice

2.1: Aspergillus niger LSPN₀₀₁ / ethanol / 120 h / 20 °C / Enzymatic reaction

With potassium hydroxide; In ethanol; 1.1: |Claisen-Schmidt Condensation / 1.2: |Claisen-Schmidt Condensation;
DOI:10.3109/10242422.2013.813489