4H-1,3-Benzodioxin-4-one, 5-(bromomethyl)-2,2-dimethyl-

Base Information

• Chemical Name: 4H-1,3-Benzodioxin-4-one, 5-(bromomethyl)-2,2-dimethyl-
• CAS No.: 507480-02-6
• Molecular Formula: C11H11BrO3
• Molecular Weight: 271.111
• DSSTox Substance ID: DTXSID00453976
• Nikkaji Number: J1.818.026J
• Wikidata: Q82275286
• Mol file: 507480-02-6.mol

Synonyms:507480-02-6;4H-1,3-Benzodioxin-4-one, 5-(bromomethyl)-2,2-dimethyl-;DTXSID00453976;2,2-Dimethyl-5-(bromomethyl)-4H-1,3-benzodioxin-4-one

Chemical Property of 4H-1,3-Benzodioxin-4-one, 5-(bromomethyl)-2,2-dimethyl-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 269.98916
• Heavy Atom Count: 15
• Complexity: 265

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OC2=CC=CC(=C2C(=O)O1)CBr)C

Technology Process of 4H-1,3-Benzodioxin-4-one, 5-(bromomethyl)-2,2-dimethyl-

There total 1 articles about 4H-1,3-Benzodioxin-4-one, 5-(bromomethyl)-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one (154714-19-9) → 5-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one (507480-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / 6 h / 0 °C

2.1: copper(l) iodide; methyllithium / tetrahydrofuran; diethyl ether / 1 h / -78 °C

2.2: 0.17 h / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 4 h / Reflux

With pyridine; N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); methyllithium; In tetrahydrofuran; tetrachloromethane; diethyl ether;

DOI:10.1021/np300468h

Reference yield: 77.0%

morpholin-4-yl-phenyl-acetonitrile (15190-10-0) + 5-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one (507480-02-6) → 2,2-dimethyl-5-(2-oxo-2-phenylethyl)-4H-benzo[d][1,3]dioxin-4-one

Guidance literature:

morpholin-4-yl-phenyl-acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at -20 ℃; for 0.333333h; Inert atmosphere;

5-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201403524

Reference yield: 73.0%

5-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one (507480-02-6) + (E)-(4S,6R,7S)-6-(4-Methoxy-benzyloxy)-7-methyl-10-tributylstannanyl-deca-1,9-dien-4-ol → 5-[(E)-(5S,6R,8S)-8-Hydroxy-6-(4-methoxy-benzyloxy)-5-methyl-undeca-2,10-dienyl]-2,2-dimethyl-benzo[1,3]dioxin-4-one (507480-11-7)

Guidance literature:

With trifuran-2-yl-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 15h;

DOI:10.1021/jo026798h

upstream raw materials:

5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

Downstream raw materials:

5-[(E)-(5S,6R,8S)-8-Hydroxy-6-(4-methoxy-benzyloxy)-5-methyl-undeca-2,10-dienyl]-2,2-dimethyl-benzo[1,3]dioxin-4-one

(E)-(7S,9R,10S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-7-(3-hydroxy-propyl)-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one

(E)-(7S,9R,10S)-7-Allyl-4-hydroxy-9-(4-methoxy-benzyloxy)-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one

(E)-(7S,9R,10S)-7-Allyl-9-(4-methoxy-benzyloxy)-10-methyl-4-triisopropylsilanyloxy-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one