2-Morpholino-2-phenylacetonitrile

Base Information

• Chemical Name: 2-Morpholino-2-phenylacetonitrile
• CAS No.: 15190-10-0
• Molecular Formula: C12H14 N2 O
• Molecular Weight: 202.256
• Hs Code.: 2934999090
• European Community (EC) Number: 239-242-9
• NSC Number: 75643
• DSSTox Substance ID: DTXSID201036004
• Nikkaji Number: J146.957F
• Wikidata: Q106902828
• ChEMBL ID: CHEMBL1896078
• Mol file: 15190-10-0.mol

Synonyms:15190-10-0;2-Morpholino-2-phenylacetonitrile;morpholin-4-yl(phenyl)acetonitrile;ALPHA-(4-MORPHOLINO)PHENYLACETONITRILE;2-(morpholin-4-yl)-2-phenylacetonitrile;Morpholino(phenyl)acetonitrile;2-morpholin-4-yl-2-phenylacetonitrile;4-Morpholineacetonitrile, .alpha.-phenyl-;Morpholin-4-yl-phenyl-acetonitrile;EINECS 239-242-9;ALPHA-(4-MORPHOLINYL)PHENYLACETONITRILE;NSC75643;Maybridge1_000080;Phenylmorpholinoacetonitrile;MixCom1_000146;NCIOpen2_004495;MLS000695203;SCHEMBL2781893;CHEMBL1896078;4-Morpholinyl(phenyl)acetonitrile;DTXSID201036004;HMS2752G24;4-Morpholinyl(phenyl)acetonitrile #;AR3596;MFCD00014619;NSC 75643;NSC-75643;STK501266;AKOS002324641;AKOS016050354;MB00240;.alpha.-Phenyl-4-morpholineacetonitrile;alpha -(4-Morpholinyl)phenylacetonitrile;NCGC00246591-01;SMR000333635;BB 0218507;CS-0171253;FT-0613312;8G-016;EN300-111076;.alpha.-(N-Morpholino)-.alpha.-phenylacetonitrile;A909864;Z447996374

Chemical Property of 2-Morpholino-2-phenylacetonitrile

Chemical Property:

• Vapor Pressure: 0.000787mmHg at 25°C
• Melting Point: 69 °C
• Boiling Point: 306.1°Cat760mmHg
• Flash Point: 138.9°C
• PSA: 36.26000
• Density: 1.139g/cm³
• LogP: 1.52138
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.110613074
• Heavy Atom Count: 15
• Complexity: 233

Purity/Quality:

97% ^*data from raw suppliers

2-Morpholino-2-phenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/22:Harmful by inhalation and if swallowed.; R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R20/22:Harmful by inhalation and if swallowed.; R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 20/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(C#N)C2=CC=CC=C2

Technology Process of 2-Morpholino-2-phenylacetonitrile

There total 23 articles about 2-Morpholino-2-phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + trimethylsilyl cyanide (7677-24-9) + benzaldehyde (100-52-7) → morpholin-4-yl-phenyl-acetonitrile (15190-10-0)

Guidance literature:

With azaphosphatrane salt on Merrifield resin; In acetonitrile; at 20 ℃; for 8h;

DOI:10.1016/j.tet.2005.09.117

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + potassium cyanide (151-50-8) + benzaldehyde (100-52-7) → morpholin-4-yl-phenyl-acetonitrile (15190-10-0)

Guidance literature:

morpholine; benzaldehyde; With perchloric acid; at 0 - 70 ℃;

potassium cyanide; In water; at 90 ℃; for 1h;

DOI:10.1016/S0957-4166(02)00487-1

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + potassium cyanide + benzaldehyde (100-52-7) → morpholin-4-yl-phenyl-acetonitrile (15190-10-0)

Guidance literature:

morpholine; benzaldehyde; With perchloric acid; In water; at 0 - 70 ℃; Inert atmosphere;

potassium cyanide; In water; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1002/jlcr.3004

upstream raw materials:

sodium cyanide

morpholin hydrochloride

potassium cyanide

benzaldehyde

Downstream raw materials:

2-(morpholin-4-yl)-2-phenylethan-1-amine

3-(4-chloro-phenyl)-2-morpholin-4-yl-3-oxo-2-phenyl-propionitrile

3-cyano-3-morpholin-4-yl-3-phenyl-propionic acid ethyl ester

morpholin-4-yl-(2-nitro-4-trifluoromethyl-phenyl)-phenyl-acetonitrile