5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Base Information

Chemical Name:5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS No.:50800-56-1
Molecular Formula:C16H13BrN2O
Molecular Weight:329.196
Hs Code.:
DSSTox Substance ID:DTXSID00439412
Nikkaji Number:J573.236K
ChEMBL ID:CHEMBL132198

Synonyms:CHEMBL132198;50800-56-1;MAZ-10;SCHEMBL2381025;DTXSID00439412;RAZRHYOBZPAGEG-UHFFFAOYSA-N;5-(4-bromophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol;5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol;BDBM50055024;5-(4-bromophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Suppliers and Price of 5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:328.02113
Heavy Atom Count:20
Complexity:419

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=N1)C3=CC=CC=C3C2(C4=CC=C(C=C4)Br)O

Technology Process of 5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

There total 4 articles about 5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1750-92-1
1-phenyl-4,5-dihydro-1H-imidazole

: 50800-56-1
5-(4-bromophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo<2,1-a>isoindole

Guidance literature:: 1-phenyl-4,5-dihydro-1H-imidazole; With n-butyllithium; at 50 ℃; for 3h;

4-methoxycarbonylphenyl bromide; at 20 ℃;
DOI:10.1016/j.bmcl.2010.04.016

Reference yield:

: 936-49-2
2-phenyl-2-imidazoline

: 619-42-1
4-methoxycarbonylphenyl bromide

: 50800-56-1
5-(4-bromophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo<2,1-a>isoindole

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 50 deg C, 3 h, 2.) THF, hexane, 50 deg C, 6 h;
DOI:10.1021/jm960288w

Reference yield:

: 100-47-0
benzonitrile

: 50800-56-1
5-(4-bromophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo<2,1-a>isoindole

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / ethane-1,2-diol / 72 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, 50 deg C, 3 h, 2.) THF, hexane, 50 deg C, 6 h

With n-butyllithium; toluene-4-sulfonic acid; In ethylene glycol;
DOI:10.1021/jm960288w