1-(methoxymethyl)-1H-indole-2,3-dione

Base Information

• Chemical Name: 1-(methoxymethyl)-1H-indole-2,3-dione
• CAS No.: 50899-39-3
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Mol file: 50899-39-3.mol

Synonyms:1-(methoxymethyl)indoline-2,3-dione;1-methoxymethylisatin;1-methoxymethylindoline-2,3-dione;1-methoxymethyl-indole-2,3-dione;1-methoxymethyl-indoline-2,3-dione;N-methoxymethyl isatin;1-Methoxymethyl-1H-indole-2,3-dione;

Chemical Property of 1-(methoxymethyl)-1H-indole-2,3-dione

Chemical Property:

• Melting Point: 99 - 100 °C (petroleum ether)
• PSA: 46.61000
• LogP: 0.88480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(methoxymethyl)-1H-indole-2,3-dione

There total 10 articles about 1-(methoxymethyl)-1H-indole-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + chloromethyl methyl ether (107-30-2) → N-methoxymethylisatin (50899-39-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/anie.200460335

Reference yield: 84.0%

1-(methoxymethyl)-1H-indole (40899-68-1) → N-methoxymethylisatin (50899-39-3)

Guidance literature:

With water; iodine; chloramine-B; potassium carbonate; In acetonitrile; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Catalytic behavior;

DOI:10.1002/ejoc.201600061

Reference yield: 83.0%

Dimethoxymethane (109-87-5) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → N-methoxymethylisatin (50899-39-3)

Guidance literature:

With boron trifluoride diethyl etherate; at 70 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.joc.7b02426

upstream raw materials:

bromethyl methyl ether

chloromethyl methyl ether

Dimethoxymethane

indole-2,3-dione

Downstream raw materials:

C₂₅H₃₀N₂O₈