40899-68-1

Basic information

• Product Name: 1H-Indole, 1-(methoxymethyl)-
• CAS NO: 40899-68-1
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol File: 40899-68-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-(methoxymethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-(methoxymethyl)-(40899-68-1)
• EPA Substance Registry System: 1H-Indole, 1-(methoxymethyl)-(40899-68-1)

Safety Data

• Hazardous Substances Data: 40899-68-1(Hazardous Substances Data)

Usage

Structure

Indole with a methoxymethyl substituent

Usage

Research and pharmaceutical purposes

Potential

Biological activities, interaction with various biological targets

Investigation

Synthesis of pharmaceutical compounds, development of drugs for various medical conditions.

Upstream product

• 120-72-9 indole 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 50899-39-3 N-methoxymethylisatin 
• 517-81-7 20-epiuleine 
• 73540-77-9 (1-methoxymethyl-indol-3-yl)carboxaldehyde 
• 135039-80-4 1-(methoxymethyl)indole-3-carboxylic acid 
• 65032-81-7 1-methyl-5H-pyrido<4,3-b>indole-3-carboxylic acid 
• 62450-07-1 3-amino-1-methyl-5H-pyrido[4,3-b]indole 
• 65136-45-0 2-ethyl-1-methyl-1H-indole 
• 68051-18-3 1-methyl-2-(1-methylpropyl)indole 

Relevant articles and documents

Regioselective oxidative arylation of indoles bearing N-alkyl protecting groups: Dual c-h functionalization via a concerted metalation-deprotonation mechanism

The most direct method for synthesizing 2-arylindoles is oxidative coupling of an arene with an indole. We have shown that both the activity and regioselectivity of this cross-coupling reaction are correlated with the acidity of the medium. This insight has been applied to predict the best conditions for the oxidative cross-coupling of N-alkylindoles, an important class of substrates that has heretofore been incompatible with the harsh conditions required for oxidative cross-coupling. Both experimental and computational data indicate that the mechanism for C-H palladation of both the indoles and simple arenes is best described as concerted metalation-deprotonation, regardless of the substitution on the arene.

SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION

Certain substituted pyrroles are antiproliferative agents useful in the treatment of cancer.

TETRAHYDRO-BETA-CARBOLINES

Tetrahydro-beta-carboline compounds having useful central nervous system activity are enclosed.