Technology Process of 2,3,6,7,10,11,14,15,18,19,22,23-Dodecaazapentacosanedioic acid,
8,20-dimethyl-4,16-bis(1-methylethyl)-12,24-bis(2-methylpropyl)-5,9,13,
17,21-pentaoxo-3,7,11,15,19,23-hexakis(phenylmethyl)-,
1-(1,1-dimethylethyl) 25-methyl ester, (4S,8S,12S,16S,20S,24S)-
There total 6 articles about 2,3,6,7,10,11,14,15,18,19,22,23-Dodecaazapentacosanedioic acid,
8,20-dimethyl-4,16-bis(1-methylethyl)-12,24-bis(2-methylpropyl)-5,9,13,
17,21-pentaoxo-3,7,11,15,19,23-hexakis(phenylmethyl)-,
1-(1,1-dimethylethyl) 25-methyl ester, (4S,8S,12S,16S,20S,24S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
dichloromethane;
at 0 - 20 ℃;
for 24h;
DOI:10.1002/hlca.200390342
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: NaOH; water / 20 °C
1.2: 86 percent / NaBH4 / 0 °C
2.1: Et4NOH / methanol
2.2: 65 percent / CH2Cl2 / cooling
3.1: 2.15 g / N-methylmorpholine; HATU / dimethylformamide / 46 h / 0 - 20 °C
4.1: 100 percent / LiOH; water / methanol / 20 °C
5.1: 182 mg / N-methylmorpholine; HATU; BOPCl / CH2Cl2 / 24 h / 0 - 20 °C
With
4-methyl-morpholine; lithium hydroxide; sodium hydroxide; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; tetraethylammonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390342
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Et4NOH / methanol
1.2: 65 percent / CH2Cl2 / cooling
2.1: 2.15 g / N-methylmorpholine; HATU / dimethylformamide / 46 h / 0 - 20 °C
3.1: 100 percent / LiOH; water / methanol / 20 °C
4.1: 182 mg / N-methylmorpholine; HATU; BOPCl / CH2Cl2 / 24 h / 0 - 20 °C
With
4-methyl-morpholine; lithium hydroxide; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; tetraethylammonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390342