(S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid

Base Information

• Chemical Name: (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid
• CAS No.: 672306-74-0
• Molecular Formula: C₄₀H₅₆N₆O₆
• Molecular Weight: 716.921
• Mol file: 672306-74-0.mol

Synonyms:(S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid

Chemical Property of (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid

There total 5 articles about (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate (509150-80-5) → (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid (672306-74-0)

Guidance literature:

With lithium hydroxide; water; In methanol; at 20 ℃;

DOI:10.1002/hlca.200390342

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid (672306-74-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaOH; water / 20 °C

1.2: 86 percent / NaBH₄ / 0 °C

2.1: Et₄NOH / methanol

2.2: 65 percent / CH₂Cl₂ / cooling

3.1: 2.15 g / N-methylmorpholine; HATU / dimethylformamide / 46 h / 0 - 20 °C

4.1: 100 percent / LiOH; water / methanol / 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydroxide; water; tetraethylammonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390342

Reference yield:

(S)-2-(benzylamino)-3-methylbutanoic acid (15363-84-5) → (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoic acid (672306-74-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Et₄NOH / methanol

1.2: 65 percent / CH₂Cl₂ / cooling

2.1: 2.15 g / N-methylmorpholine; HATU / dimethylformamide / 46 h / 0 - 20 °C

3.1: 100 percent / LiOH; water / methanol / 20 °C

With 4-methyl-morpholine; lithium hydroxide; water; tetraethylammonium hydroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200390342

upstream raw materials:

methyl (S)-2-(1-benzyl-2-{(S)-2-[1-benzyl-2-((S)-2-{1-benzyl-2-[(tert-butoxy)carbonyl]hydrazino}-3-methylbutanoyl)hydrazino]propanoyl}hydrazino)-4-methylpentanoate

L-valine

(S)-2-(benzylamino)-3-methylbutanoic acid

benzaldehyde

Downstream raw materials:

C₇₆H₁₀₄N₁₂O₉