Pentanoic acid, 5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-5-[[[3-(trifluoromethyl)phenyl] methyl]amino]-, 1,1-dimethylethyl ester, (4R)-

Base Information

• Chemical Name: Pentanoic acid, 5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-5-[[[3-(trifluoromethyl)phenyl] methyl]amino]-, 1,1-dimethylethyl ester, (4R)-
• CAS No.: 512783-86-7
• Molecular Formula: C25H29F3N2O5
• Molecular Weight: 494.511
• Mol file: 512783-86-7.mol

Synonyms:

Chemical Property of Pentanoic acid, 5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-5-[[[3-(trifluoromethyl)phenyl] methyl]amino]-, 1,1-dimethylethyl ester, (4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-5-[[[3-(trifluoromethyl)phenyl] methyl]amino]-, 1,1-dimethylethyl ester, (4R)-

There total 2 articles about Pentanoic acid, 5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-5-[[[3-(trifluoromethyl)phenyl] methyl]amino]-, 1,1-dimethylethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(TRIFLUOROMETHYL)BENZYLAMINE (2740-83-2) + N-(benzyloxy)carbonyl-D-glutamic acid 5-tert-butyl ester (51644-83-8) → N-[(benzyloxy)carbonyl]-D-glutamic acid γ-tert-butyl ester α-[3-(trifluoromethyl)benzyl]amide (512783-86-7)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2006.12.031

Reference yield: 100.0%

→ N-[(benzyloxy)carbonyl]-D-glutamic acid γ-tert-butyl ester α-[3-(trifluoromethyl)benzyl]amide (512783-86-7)

Guidance literature:

Reference yield: 94.0%

N-[(benzyloxy)carbonyl]-D-glutamic acid γ-tert-butyl ester α-[3-(trifluoromethyl)benzyl]amide (512783-86-7) → D-glutamic acid γ-tert-butyl ester α-[3-(trifluoromethyl)benzyl]amide (512783-93-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.bmc.2006.12.031

upstream raw materials:

3-(TRIFLUOROMETHYL)BENZYLAMINE

N-(benzyloxy)carbonyl-D-glutamic acid 5-tert-butyl ester

Downstream raw materials:

D-glutamic acid γ-tert-butyl ester α-[3-(trifluoromethyl)benzyl]amide

4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid tert-butyl ester