4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

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Chemical Name:4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid
CAS No.:512784-08-6
Molecular Formula:C₃₃H₃₀F₃N₃O₆
Molecular Weight:621.613
Hs Code.:

Synonyms:4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

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Chemical Property of 4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

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Technology Process of 4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

There total 9 articles about 4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 512784-00-8
4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid tert-butyl ester

: 512784-08-6
4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

Guidance literature:: With formic acid; at 20 ℃;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 512783-86-7
N-[(benzyloxy)carbonyl]-D-glutamic acid γ-tert-butyl ester α-[3-(trifluoromethyl)benzyl]amide

: 512784-08-6
4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / hydrogen / palladium on carbon / methanol

2: magnesium sulfate / CH₂Cl₂ / 20 °C

3: 1.84 mg / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 100 percent / formic acid / 20 °C

With formic acid; hydrogen; magnesium sulfate; palladium on activated charcoal; In methanol; dichloromethane; 3: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 512784-08-6
4-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-4-(3-trifluoromethyl-benzylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

2: 94 percent / hydrogen / palladium on carbon / methanol

3: magnesium sulfate / CH₂Cl₂ / 20 °C

4: 1.84 mg / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

5: 100 percent / formic acid / 20 °C

With formic acid; 1-hydroxy-7-aza-benzotriazole; hydrogen; magnesium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; 4: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031