Piperazine, 1-[[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenoxy] acetyl]-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, (2R,5S)-

Base Information

• Chemical Name: Piperazine, 1-[[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenoxy] acetyl]-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, (2R,5S)-
• CAS No.: 519171-97-2
• Molecular Formula: C30H29ClFN3O4
• Molecular Weight: 550.029

Synonyms:

Chemical Property of Piperazine, 1-[[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenoxy] acetyl]-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, (2R,5S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Piperazine, 1-[[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenoxy] acetyl]-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, (2R,5S)-

There total 1 articles about Piperazine, 1-[[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenoxy] acetyl]-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-, (2R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone (217648-11-8) + 2-(5-chloro-2-hydroxy-benzyl)isoindole-1,3-dione (331729-64-7) → 2-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-isoindole-1,3-dione (519171-97-2)

Guidance literature:

With potassium iodide; potassium carbonate; In N-methyl-acetamide;

Reference yield:

2-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-isoindole-1,3-dione (519171-97-2) → 2-(2-aminomethyl-4-chloro-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone (364067-02-7)

Guidance literature:

With hydrazine; In ethanol;

upstream raw materials:

2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

2-(5-chloro-2-hydroxy-benzyl)isoindole-1,3-dione

Downstream raw materials:

2-(2-aminomethyl-4-chloro-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

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