2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

Base Information

Chemical Name:2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone
CAS No.:217648-11-8
Molecular Formula:C₁₅H₂₀ClFN₂O
Molecular Weight:298.788
Hs Code.:

Synonyms:2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

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Technology Process of 2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

There total 6 articles about 2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364066-92-2
(2S,5R)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine

: 79-04-9
chloroacetyl chloride

: 217648-11-8
2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

Guidance literature:: With triethylamine; In toluene; at 0 - 10 ℃; for 1h;

Reference yield:

: 478833-41-9
(2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine

: 79-04-9
chloroacetyl chloride

: 217648-11-8
2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: C₄H₆O₆*C₁₃H₁₉FN₂

: 79-04-9
chloroacetyl chloride

: 217648-11-8
2-chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

Guidance literature:: With sodium hydroxide; In 2-methyltetrahydrofuran; water; at 20 - 25 ℃; for 0.916667h; Inert atmosphere;
DOI:10.1021/op7000386