(-)-CHLORPHENIRAMINE MALEATE

Base Information

• Chemical Name: (-)-CHLORPHENIRAMINE MALEATE
• CAS No.: 23095-76-3
• Molecular Formula: C20H23ClN2O4
• Molecular Weight: 390.867
• Hs Code.: 2933399090
• Mol file: 23095-76-3.mol

Synonyms:(R)-(-)-Chlorpheniramine maleate;2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (R)-, (2Z)-2-butenedioate (1:1);2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (R)-, (Z)-2-butenedioate (1:1);2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (γR)-, (2Z)-2-butenedioate (1:1);2-Pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (R)-, (2Z)-2-butenedioate (1:1)

Chemical Property of (-)-CHLORPHENIRAMINE MALEATE

Chemical Property:

• Vapor Pressure: 5.88E-07mmHg at 25°C
• Boiling Point: 395.3 °C at 760 mmHg
• Flash Point: 192.8 °C
• PSA: 90.73000
• Density: g/cm³
• LogP: 3.53040
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), DMF (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(R)-(-)-ChlorpheniramineMaleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The R-enantiomer of Chlorpheniramine (C424300). Antihistaminic.

Technology Process of (-)-CHLORPHENIRAMINE MALEATE

There total 1 articles about (-)-CHLORPHENIRAMINE MALEATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorphenamine maleate (113-92-8) → dextrochlorpheniramine maleate (2438-32-6) + (-)-Chlorpheniramine maleate (23095-76-3)

Guidance literature:

With sodium dihydrogenphosphate; phosphoric acid; In methanol; water; pH=2.75; Reagent/catalyst; Ionic liquid; Resolution of racemate;

DOI:10.1002/chir.22168

Reference yield:

(-)-Chlorpheniramine maleate (23095-76-3) → R-(-)-monodesmethylchlorpheniramine

Guidance literature:

With α-D-glucose 6-phosphate; Wistar rat liver microsomes; NADP; In phosphate buffer; at 37 ℃; for 0.5h; Further Variations:; Reaction partners; Enzyme kinetics; Enzymatic reaction;

DOI:10.1111/j.2042-7158.1997.tb06791.x

upstream raw materials:

chlorphenamine maleate

Refernces

• 1、 Xu, Guangfu,Du, Yingxiang,Du, Fan,Chen, Jiaquan,Yu, Tao,Zhang, Qi,Zhang, Jinjing,Du, Shuaijing,Feng, Zijie. "Establishment and Evaluation of the Novel Tetramethylammonium-L-Hydroxyproline Chiral Ionic Liquid Synergistic System Based on Clindamycin Phosphate for Enantioseparation by Capillary Electrophoresis". supporting information. p. 598 - 604. Retrieved 2015/08/25.
• 2、 Cui, Yan,Ma, Xiaowei,Zhao, Min,Jiang, Zhen,Xu, Shuying,Guo, Xingjie. "Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis". . p. 409 - 414. Retrieved 2013/07/26.