Chlorphenamine maleates

Base Information

• Chemical Name: Chlorphenamine maleates
• CAS No.: 113-92-8
• Molecular Formula: C20H23ClN2O4
• Molecular Weight: 390.867
• Hs Code.: 29333990
• Mol file: 113-92-8.mol

Synonyms:Phenetron;Polaronil;Teldrin;Chlor-trimeton;Chlorphenamine maleates;C16-H19-Cl-N2.C4-H4-O4;2-Piridinpropanamina,. Gamma .-(4-clorofenil)-N,N-dimetil-, (2Z)-2-butenodioato (1:1);2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);2-Pyridinepropanamine, ?-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1);Chlorphenamine Maleate,(S);HMS3369F09;HMS3371M22;HMS3373A05;HMS3393L14;HMS3394E15;HMS3655G14;BCP09631;AKOS030228309;SB19136;PD046142;FT-0623712;FT-0665003;FT-0665004;FT-0665005

Chemical Property of Chlorphenamine maleates

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.9E-14mmHg at 25°C
• Melting Point: 130-135 ºC
• Refractive Index: 1.6800 (estimate)
• Boiling Point: 379 ºC at 760 mmHg
• Flash Point: 183 ºC
• PSA: 90.73000
• Density: 1.107 g/cm³
• LogP: 3.53040
• Storage Temp.: -20°C Freezer
• Solubility.: Freely soluble in water, soluble in ethanol (96 per cent)
• Water Solubility.: 1-5 g/100 mL at 21 ºC
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 390.1346349
• Heavy Atom Count: 27
• Complexity: 368

Purity/Quality:

99%, ^*data from raw suppliers

ChlorpheniramineMaleateSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,F
• Statements: 25-39/23/24/25-23/24/25-11
• Safety Statements: 36/37/39-45-36/37-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
• Description: Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.
• Uses: An antagonist of the histamine H1-receptor Antihistaminic (±)-Chlorpheniramine maleate salt has been used:as H1 receptor antagonist to determine the receptor functionto block the effect of compound 48/80 on plasma IGF-Ias a standard for fast sensing and determination by sequential injector coupled with potentiometer

Technology Process of Chlorphenamine maleates

There total 10 articles about Chlorphenamine maleates which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

maleic acid (110-16-7,26099-09-2) + Chlorpheniramine (132-22-9) → chlorphenamine maleate (113-92-8)

Guidance literature:

In ethanol; n-heptane; at 55 ℃;

Reference yield: 88.8%

formic acid (64-18-6) + Didesmethylchlorpheniramine (20619-13-0) + maleic acid (110-16-7,26099-09-2) → chlorphenamine maleate (113-92-8)

Guidance literature:

formic acid; Didesmethylchlorpheniramine; In water; N,N-dimethyl-formamide; at 100 ℃; for 24h;

maleic acid; In isopropyl alcohol; at 80 ℃; for 2h;

Reference yield: 54.4%

2-(4-chlorobenzyl)pyridine (4350-41-8) + 2-(dimethylamino)ethyl chloride (107-99-3) + maleic acid (110-16-7,26099-09-2) → chlorphenamine maleate (113-92-8)

Guidance literature:

2-(4-chlorobenzyl)pyridine; With sodium amide; In toluene; Reflux;

2-(dimethylamino)ethyl chloride; In toluene; for 6h; Reflux;

maleic acid; In water;

upstream raw materials:

p-chlorobenzyl cyanide

maleic acid

Chlorpheniramine

2-(4-chlorobenzyl)pyridine

Downstream raw materials:

dextrochlorpheniramine maleate

(-)-Chlorpheniramine maleate

Refernces

• 1、 -. "Chlorpheniramine maleate salifying substance and synthesis method and application thereof". Paragraph 0024-0035. . Retrieved 2020/08/25.
• 2、 -. "1/10-water maleic acid chlorpheniramine compound and pharmaceutical composition thereof (by machine translation)". Paragraph 0090-0091; 0094-0099. . Retrieved 2020/07/28.