Benzamide, N-(4-fluorophenyl)-2-methoxy-

Base Information

Chemical Name:Benzamide, N-(4-fluorophenyl)-2-methoxy-
CAS No.:5215-38-3
Molecular Formula:C14H12FNO2
Molecular Weight:245.24900
Hs Code.:
DSSTox Substance ID:DTXSID801286524
Mol file:5215-38-3.mol

Synonyms:N-(4-fluorophenyl)-2-methoxybenzamide;Benzamide, N-(4-fluorophenyl)-2-methoxy-;5215-38-3;Oprea1_256683;Oprea1_836867;SCHEMBL4429130;DTXSID801286524;MFCD00752530;STK021309;AKOS003241821;AB00081247-01

Suppliers and Price of Benzamide, N-(4-fluorophenyl)-2-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Benzamide, N-(4-fluorophenyl)-2-methoxy-

Chemical Property:

PSA：38.33000
LogP:3.15960
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:245.08520679
Heavy Atom Count:18
Complexity:277

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)F

Technology Process of Benzamide, N-(4-fluorophenyl)-2-methoxy-

There total 3 articles about Benzamide, N-(4-fluorophenyl)-2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 21615-34-9
2-Methoxybenzoyl chloride

: 371-40-4
4-fluoroaniline

: 5215-38-3
N-4-fluorophenyl-2-methoxybenzamide

Guidance literature:: With pyridine; In dichloromethane; at 30 ℃;
DOI:10.14233/ajchem.2013.13895

Reference yield: 27.0%

: 1195-45-5
para-fluorophenyl isocyanate

: 282727-20-2
(2-methoxyphenyl)zinc(II) iodide

: 5215-38-3
N-4-fluorophenyl-2-methoxybenzamide

Guidance literature:: para-fluorophenyl isocyanate; With [Rh(OH)(cod)]2; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

(2-methoxyphenyl)zinc(II) iodide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.orglett.0c00729

Reference yield:

: 529-28-2
4-iodoanisol

: 5215-38-3
N-4-fluorophenyl-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane; lithium chloride; indium(III) chloride / tetrahydrofuran / 250 °C / Inert atmosphere; Schlenk technique

2.1: [Rh(OH)(cod)]2 / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

With indium(III) chloride; chloro-trimethyl-silane; [Rh(OH)(cod)]2; lithium chloride; In tetrahydrofuran;
DOI:10.1021/acs.orglett.0c00729