2-ethyl-2-(3-hydroxypropyl)propanedioic acid

Base Information

• Chemical Name: 2-ethyl-2-(3-hydroxypropyl)propanedioic acid
• CAS No.: 52250-47-2
• Molecular Formula: C8H14O5
• Molecular Weight: 190.19400
• Mol file: 52250-47-2.mol

Synonyms:2-Ethyl-2-(3-hydroxy-propyl)-malonic acid;Aethyl-γ-hydroxypropylmalonsaeure;

Chemical Property of 2-ethyl-2-(3-hydroxypropyl)propanedioic acid

Chemical Property:

• Vapor Pressure: 5.76E-08mmHg at 25°C
• Melting Point: 129 - 130 °C
• PSA: 94.83000
• LogP: 0.32450

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-2-(3-hydroxypropyl)propanedioic acid

There total 3 articles about 2-ethyl-2-(3-hydroxypropyl)propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl ethyl(3-chloropropyl)malonate (32821-60-6) → Aethyl-γ-Hydroxy-propylmalonsaeure (52250-47-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/0040-4020(77)84062-3

Reference yield:

ethyl diethyl malonate (133-13-1) → Aethyl-γ-Hydroxy-propylmalonsaeure (52250-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaOEt, EtOH, (ii) /BRN= 605278/

2: aq. NaOH

With sodium hydroxide;

DOI:10.1016/0040-4020(77)84062-3

Reference yield:

→ Aethyl-γ-Hydroxy-propylmalonsaeure (52250-47-2)

Guidance literature:

Aethyl-γ-chlorpropylmalonsaeure-ester, NaOH(aq) / EtOH, Δ;

upstream raw materials:

diethyl ethyl(3-chloropropyl)malonate

ethyl diethyl malonate

Refernces