N-[4-(2-chloroethyl)phenyl]acetamide

Base Information

Chemical Name:N-[4-(2-chloroethyl)phenyl]acetamide
CAS No.:52273-67-3
Molecular Formula:C10H12ClNO
Molecular Weight:197.66100
Hs Code.:
DSSTox Substance ID:DTXSID70454258
Wikidata:Q82275675
Mol file:52273-67-3.mol

Synonyms:N-[4-(2-chloroethyl)phenyl]acetamide;Acetamide, N-[4-(2-chloroethyl)phenyl]-;52273-67-3;SCHEMBL7393223;DTXSID70454258;YGKNSAIBTCSDDZ-UHFFFAOYSA-N

Suppliers and Price of N-[4-(2-chloroethyl)phenyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-[4-(2-chloroethyl)phenyl]acetamide

Chemical Property:

Melting Point:117-119 °C
Boiling Point:381.0±25.0 °C(Predicted)
PSA：32.59000
Density:1.185±0.06 g/cm3(Predicted)
LogP:3.07580
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:197.0607417
Heavy Atom Count:13
Complexity:164

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1=CC=C(C=C1)CCCl

Technology Process of N-[4-(2-chloroethyl)phenyl]acetamide

There total 4 articles about N-[4-(2-chloroethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 81865-10-3
2-(4-aminophenyl)ethyl chloride

: 108-24-7
acetic anhydride

: 52273-67-3
N-[4-(2-chloro-ethyl)-phenyl]-acetamide

Guidance literature:: With pyridine; at 20 ℃; for 24h;
DOI:10.1021/jm010924c

Reference yield:

: 20264-95-3
2-(4-nitrophenyl)ethyl chloride

: 52273-67-3
N-[4-(2-chloro-ethyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / H₂ / 10percent Pd/C / methanol / 0.17 h / 2068.65 Torr

2: 68 percent / pyridine / 24 h / 20 °C

With pyridine; hydrogen; 10percent Pd/C; In methanol;
DOI:10.1021/jm010924c

Reference yield:

: 622-24-2
2-phenylethyl chloride

: 52273-67-3
N-[4-(2-chloro-ethyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / 90 percent HNO₃ / 0.33 h / 0 °C

2: 96 percent / H₂ / 10percent Pd/C / methanol / 0.17 h / 2068.65 Torr

3: 68 percent / pyridine / 24 h / 20 °C

With pyridine; hydrogen; nitric acid; 10percent Pd/C; In methanol;
DOI:10.1021/jm010924c