N-(4-chlorophenyl)morpholine-4-carboxamide

Base Information

• Chemical Name: N-(4-chlorophenyl)morpholine-4-carboxamide
• CAS No.: 52625-27-1
• Molecular Formula: C11H13ClN2O2
• Molecular Weight: 240.689
• European Community (EC) Number: 688-800-1
• Nikkaji Number: J3.585.584J
• ChEMBL ID: CHEMBL1486933
• Mol file: 52625-27-1.mol

Synonyms:N-(4-chlorophenyl)morpholine-4-carboxamide;Morpholine-4-carboxylic acid (4-chloro-phenyl)-amide;52625-27-1;N-(4-chlorophenyl)-4-morpholinecarboxamide;Cambridge id 5191768;MLS001203339;CHEMBL1486933;SCHEMBL10594359;HMS2843G20;STL282662;AKOS000621678;CCG-108292;SMR000516356;SR-01000455000;SR-01000455000-1;Z44590812

Chemical Property of N-(4-chlorophenyl)morpholine-4-carboxamide

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 240.0665554
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)NC2=CC=C(C=C2)Cl

Technology Process of N-(4-chlorophenyl)morpholine-4-carboxamide

There total 16 articles about N-(4-chlorophenyl)morpholine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

morpholine (110-91-8,99108-56-2) + p-chlorphenylisocyanate (104-12-1) → N-(4-chlorophenyl)morpholine-4-carboxamide (52625-27-1)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 18h;

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 4-Chlorophenyl isothiocyanate (2131-55-7) → N-(4-chlorophenyl)morpholine-4-carboxamide (52625-27-1)

Guidance literature:

With eosin Y; oxygen; In water; dimethyl sulfoxide; at 20 ℃; for 8h; Schlenk technique; Sealed tube; Irradiation; Green chemistry;

DOI:10.1039/d0gc00070a

Reference yield: 85.0%

morpholine-4-carboxylic acid amide (2158-02-3) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)morpholine-4-carboxamide (52625-27-1)

Guidance literature:

With nano-Fe₃O₄-supported sulfonic acid; In neat (no solvent); at 120 ℃; for 2h; chemoselective reaction; Green chemistry;

DOI:10.1055/s-0036-1588319

upstream raw materials:

morpholine

p-chlorphenylisocyanate

4-(trimethylsilyl)morpholine

N-(4-chlorophenyl)-2,2,2,-trichloroacetamide

Refernces

• 1、 Sanabria, Carlos M.,Costa, Bruno B. S.,Viana, Gil M.,De Aguiar, Lúcia C. S.,De Mattos, Marcio C. S.. "Efficient Direct Halogenation of Unsymmetrical N -Benzyl- and N -Phenylureas with Trihaloisocyanuric Acids". . p. 1359 - 1367. Retrieved 2017/12/26.
• 2、 Kothandapani, Jagatheeswaran,Ganesan, Asaithampi,Ganesan, Subramaniapillai Selva. "Nano-Magnetic Sulfonic Acid Catalyzed Facile Synthesis of Diverse Amide Derivatives". . p. 685 - 692. Retrieved 2017/01/25.