2-Pyrrolidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester), (2S)-

Base Information

Chemical Name:2-Pyrrolidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester), (2S)-
CAS No.:52682-03-8
Molecular Formula:C19H23NO5S2
Molecular Weight:409.527
Hs Code.:
Mol file:52682-03-8.mol

Synonyms:(S)-N,O-bis(tosyl)prolinol;(S)-1-(Toluol-4-sulfonyl)-2-(toluol-4-sulfonyloxymethyl)-pyrrolidin;(-)-(S)-N,O-bis(p-tolylsulfonyl)-2-pyrrolidyl methanol;(S)-1-(toluene-4-sulfonyl)-2-(toluene-4-sulfonyloxymethyl)-pyrrolidine;(S)-N,O-bis(p-toluenesulfonyl)-2-(hydroxymethyl)pyrrolidine;N,O-bis-tosyl-L-prolinol;

Suppliers and Price of 2-Pyrrolidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester), (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2-Pyrrolidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester), (2S)-

Chemical Property:

Melting Point:96-98 °C
Boiling Point:575.0±52.0 °C(Predicted)
PSA：97.51000
Density:1.307±0.06 g/cm3(Predicted)
LogP:4.96150

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester), (2S)-

There total 5 articles about 2-Pyrrolidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester), (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

: 98-59-9
p-toluenesulfonyl chloride

: 498-63-5
2-hydroxymethylpyrrolidine

: 52682-03-8
1-(toluene-4-sulfonyl)-2-(toluene-4-sulfonyloxymethyl)-pyrrolidine

Guidance literature:: With pyridine; at 0 - 20 ℃; for 19h;
DOI:10.1039/c7ob02659e

Reference yield: 79.0%

: 55456-48-9
((2S)-1-p-toluenesulfonyl-2-pyrrolidinyl)methanol

: 98-59-9
p-toluenesulfonyl chloride

: 52682-03-8
(S)(-)-N,O-bis(p-toluenesulphonyl)-2-hydroxymethyl pyrrolidine

Guidance literature:: With sodium hydroxide; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00560f

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 52682-03-8
(S)(-)-N,O-bis(p-toluenesulphonyl)-2-hydroxymethyl pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / Zn(BH₄)2 / tetrahydrofuran / 10 h / Heating

2: 89 percent / pyridine / 12 h / 20 °C

With zinc(II) tetrahydroborate; In tetrahydrofuran; pyridine;
DOI:10.1016/j.carres.2004.11.016