ethyl 6-phenylhexanoate

Base Information

• Chemical Name: ethyl 6-phenylhexanoate
• CAS No.: 52692-51-0
• Molecular Formula: C14H20O2
• Molecular Weight: 220.312
• Mol file: 52692-51-0.mol

Synonyms:

Chemical Property of ethyl 6-phenylhexanoate

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-phenylhexanoate

There total 16 articles about ethyl 6-phenylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 6-iodohexanoate (13159-24-5) + phenylmagnesium bromide → 6-phenylhexanoic acid ethyl ester (52692-51-0)

Guidance literature:

phenylmagnesium bromide; With dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; In tetrahydrofuran; at 20 ℃; for 1h;

ethyl 6-iodohexanoate; With iron(III) chloride; In tetrahydrofuran; at 50 ℃; for 0.5h;

DOI:10.1055/s-2005-871541

Reference yield: 95.0%

6-<(4-methylbenzenesulfonyl)oxy>hexanoic acid, ethyl ester (122822-50-8) + phenylmagnesium bromide (100-58-3) → 6-phenylhexanoic acid ethyl ester (52692-51-0)

Guidance literature:

phenylmagnesium bromide; With ZnI₂(tmeda); In tetrahydrofuran;

6-<(4-methylbenzenesulfonyl)oxy>hexanoic acid, ethyl ester; With iron(III) chloride; In tetrahydrofuran; at 0 - 25 ℃;

DOI:10.1021/ol901610a

Reference yield: 85.0%

4-Phenylbut-1-ene (768-56-9) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → 6-phenylhexanoic acid ethyl ester (52692-51-0)

Guidance literature:

With pentafluorophenylthiol; tris[2-phenylpyridinato-C²,N]iridium(III); ascorbic acid; In 1,2-dimethoxyethane; water; at 20 ℃; for 64h; regioselective reaction; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.201809115

upstream raw materials:

ethyl 6-oxo-6-phenylhexanoate

cis-1-(trans-β-Ethoxycarbonylvinyl)-2-phenylcyclopropan

4-Phenylbut-1-ene

ethyl bromoacetate

Downstream raw materials:

6-phenyl-hexanoic acid hydrazide

4-Hydroxy-1-phenyl-3-(4-phenyl-butyl)-1H-[1,8]naphthyridin-2-one

5-(4-phenyl-butyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

(RS)-2-phenylcyclohexanone