2-Phenethoxytetrahydrofuran

Base Information

• Chemical Name: 2-Phenethoxytetrahydrofuran
• CAS No.: 52767-51-8
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID60457930
• Nikkaji Number: J1.375.147A
• Mol file: 52767-51-8.mol

Synonyms:2-Phenethoxytetrahydrofuran;52767-51-8;2-(2-PHENYLETHOXY)OXOLANE;2-phenethyloxy-tetrahydro-furan;2-(2-phenylethoxy)tetrahydrofuran;Furan, tetrahydro-2-(2-phenylethoxy)-;2-(Phenethyloxy)tetrahydrofuran;DTXSID60457930;AKOS015908149

Chemical Property of 2-Phenethoxytetrahydrofuran

Chemical Property:

• PSA: 18.46000
• LogP: 2.38220
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 192.115029749
• Heavy Atom Count: 14
• Complexity: 152

Purity/Quality:

98% ^*data from raw suppliers

2-Phenethoxytetrahydrofuran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(OC1)OCCC2=CC=CC=C2

Technology Process of 2-Phenethoxytetrahydrofuran

There total 7 articles about 2-Phenethoxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 2-phenylethanol (60-12-8) → (±)-2-phenethoxytetrahydrofuran (52767-51-8)

Guidance literature:

With (Bu₄N)₂S₂O₈; for 0.67h; Heating;

DOI:10.1016/S0040-4039(00)73641-0

Reference yield: 83.1%

2-hydroxytetrahydrofuran (5371-52-8) + 2-phenylethanol (60-12-8) → (±)-2-phenethoxytetrahydrofuran (52767-51-8)

Guidance literature:

With rhenium(VII) oxide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.3762/bjoc.9.174

Reference yield: 70.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 2-phenylethanol (60-12-8) + 2-nitrosotetrahydrofuran → (±)-2-phenethoxytetrahydrofuran (52767-51-8)

Guidance literature:

With oxygen; at 90 ℃; for 20h; Reagent/catalyst; Schlenk technique; Green chemistry;

DOI:10.1016/j.tetlet.2020.152251

upstream raw materials:

tetrahydrofuran

2-phenylethanol

2-(2-phenylethoxy)tetrahydro-2H-pyran

2-hydroxytetrahydrofuran

Refernces

• 1、 Kobayashi, Shoji,Tamura, Tomoki,Yoshimoto, Saki,Kawakami, Takashi,Masuyama, Araki. "4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent". . p. 3921 - 3937. Retrieved 2019/11/11.
• 2、 Sittiwong, Wantanee,Richardson, Michael W.,Schiaffo, Charles E.,Fisher, Thomas J.,Dussault, Patrick H.. "Re2O7-catalyzed reaction of hemiacetals and aldehydes with O-, S-, and C-nucleophiles". . p. 1526 - 1532. Retrieved 2013/10/22.