60-12-8

Basic information

• Product Name: Phenethyl alcohol
• Synonyms: RARECHEM AL BD 0140;PHENYL ETHYL ALCHOL;PHENYL ETHYL ALCOHOL;PHENYL ETHANOL;PHENYLETHANOL,2-;PHENETHYL ALCOHOL;(beta-pea);.beta.-Phenylethanol
• CAS NO: 60-12-8
• Molecular Formula: C₈H₁₀O
• Molecular Weight: 122.16
• EINECS: 200-456-2
• Product Categories: Miscellaneous;Aromatics;Miscellaneous Reagents;Alcohols;Aspalathus linearis (Rooibos tea);Building Blocks;C7 to C8;Chemical Synthesis;Citrus aurantium (Seville orange);Humulus lupulus (Hops);Nutrition Research;Ocimum basilicum (Basil);Organic Building Blocks;Oxygen Compounds;Phytochemicals by Plant (Food/Spice/Herb);Sambucus nigra (Elderberry);Vaccinium myrtillus (Bilberry);Pyridines ,Halogenated Heterocycles
• Mol File: 60-12-8.mol
• Article Data: 1023

Chemical Properties

• Melting Point: −27 °C(lit.)
• Boiling Point: 219-221 °C750 mm Hg(lit.)
• Flash Point: 216 °F
• Appearance: Clear colorless/Liquid
• Density: 1.020 g/mL at 20 °C(lit.)
• Vapor Density: 4.21 (vs air)
• Vapor Pressure: 1 mm Hg ( 58 °C)
• Refractive Index: n20/D 1.5317(lit.)
• Storage Temp.: Store at RT.
• Solubility: Miscible with chloroform.
• PKA: 15.17±0.10(Predicted)
• Explosive Limit: 1.4-11.9%(V)
• Water Solubility: 20 g/L (20 ºC)
• Stability: Stable. Substances to be avoided include strong acids and strong oxidizing agents. Combustible.
• Merck: 14,7224
• BRN: 1905732
• CAS DataBase Reference: Phenethyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: Phenethyl alcohol(60-12-8)
• EPA Substance Registry System: Phenethyl alcohol(60-12-8)

Safety Data

• Hazard Codes: Xn
• Statements: 21/22-36/38-36-22
• Safety Statements: 26-28-36/37-36/37/39
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 1
• RTECS: SG7175000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 60-12-8(Hazardous Substances Data)

Usage

Edible spices

Different sources of media describe the Edible spices of 60-12-8 differently. You can refer to the following data:
1. Phenethyl alcohol is a kind of edible spices, and naturally exists in neroli, rose oil, geranium oil and other oils, because it has a soft, pleasant and persistent rose fragrance and is widely used in various kinds of flavors and cigarette flavor. It is dispensing rose scent, food additives, the main raw material for rose scent flavor, stable on alkali, which are widely used in soap fragrance, is essence blending all rose scent series of spices, because it does not dissolve in water, it is often used in the making up water, soap and orange flower, purple, etc. It is also used in the blending of flavor. Because the Phenethyl alcohol has a good antibacterial efficiency, it can be used in the ophthalmic solution. At present there are main three synthesis methods as following: 1, by styrene via halogenation, saponification, hydrogenation, distillation. 2, and microorganism fermentation in yeast by bioconversion. 3, calcium carbide, benzene as raw material preparation of benzyl ethanol, reaction equations are as follows: 1)CaC2+2H2O=Ca(OH)2+C2H2 2)C6H6+C2H2=C6H6CHCH2（Styrene） 3)C6H6CHCH2＋H2O=C6H6CH2CH2OH（Phenylethyl alcohol）
2. Phenethyl alcohol is a kind of edible spices, and naturally exists in neroli, rose oil, geranium oil and other oils, because it has a soft, pleasant and persistent rose fragrance and is widely used in various kinds of flavors and cigarette flavor. It is dispensing rose scent, food additives, the main raw material for rose scent flavor, stable on alkali, which are widely used in soap fragrance, is essence blending all rose scent series of spices, because it does not dissolve in water, it is often used in the making up water, soap and orange flower, purple, etc. It is also used in the blending of flavor. Because the Phenethyl alcohol has a good antibacterial efficiency, it can be used in the ophthalmic solution. At present there are main three synthesis methods as following: 1, by styrene via halogenation, saponification, hydrogenation, distillation. 2, and microorganism fermentation in yeast by bioconversion. 3, calcium carbide, benzene as raw material preparation of benzyl ethanol, reaction equations are as follows: 1)CaC2+2H2O=Ca(OH)2+C2H2 2)C6H6+C2H2=C6H6CHCH2（Styrene） 3)C6H6CHCH2＋H2O=C6H6CH2CH2OH（Phenylethyl alcohol）

Chemical Properties

Different sources of media describe the Chemical Properties of 60-12-8 differently. You can refer to the following data:
1. Phenethyl alcohol is a clear, colorless liquid with an odor of rose oil. It has a burning taste that irritates and then anesthetizes mucous membranes. Phenethyl Alcohol (PEA) is an aromatic alcohol that is used as a fragrance and an antimicrobial preservative in cosmetic formulations. It is active at pH 6 or less and is inactivated by nonionic detergents including polysorbate-80. PEA is also a widely used fragrance material that imparts a rose character to perfume compositions. Almost all rose fragrances and other floral-type perfumes contain PEA, and PEA is used extensively for many other fragrance applications because it blends ell. PEA is metabolized to phenylacetic acid in mammals. In humans, it is excreted in urine as the conjugate phenylacetylglutamine.
2. Phenethyl alcohol is the main component of rose oils obtained from rose blossoms. It occurs in smaller quantities in neroli oil, ylang-ylang oil, carnation oil, and geranium oils. Since the alcohol is rather soluble in water, losses occur when essential oils are produced by steam distillation. Phenylethyl alcohol is a colorless liquid with a mild rose odor. It can be dehydrogenated catalytically to phenylacetaldehyde and oxidized to phenylacetic acid (e.g.,with chromic acid). Its fatty acid esterswith lowermolecularmass, as well as some alkyl ethers, are valuable fragrance and flavor substances.
3. Phenethyl alcohol has a characteristic rose-like odor and an initially slightly bitter taste, then sweet and reminiscent of peach.
4. Phenethyl alcohol is a clear, colorless liquid with an odor of rose oil. It has a burning taste that irritates and then anesthetizes mucous membranes. Phenethyl Alcohol (PEA) is an aromatic alcohol that is used as a fragrance and an antimicrobial preservative in cosmetic formulations. It is active at pH 6 or less and is inactivated by nonionic detergents including polysorbate-80. PEA is also a widely used fragrance material that imparts a rose character to perfume compositions. Almost all rose fragrances and other floral-type perfumes contain PEA, and PEA is used extensively for many other fragrance applications because it blends ell. PEA is metabolized to phenylacetic acid in mammals. In humans, it is excreted in urine as the conjugate phenylacetylglutamine.
5. Phenethyl alcohol is the main component of rose oils obtained from rose blossoms. It occurs in smaller quantities in neroli oil, ylang-ylang oil, carnation oil, and geranium oils. Since the alcohol is rather soluble in water, losses occur when essential oils are produced by steam distillation. Phenylethyl alcohol is a colorless liquid with a mild rose odor. It can be dehydrogenated catalytically to phenylacetaldehyde and oxidized to phenylacetic acid (e.g.,with chromic acid). Its fatty acid esterswith lowermolecularmass, as well as some alkyl ethers, are valuable fragrance and flavor substances.
6. Phenethyl alcohol has a characteristic rose-like odor and an initially slightly bitter taste, then sweet and reminiscent of peach.

Uses

Different sources of media describe the Uses of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol is qualitatively and quantitatively one of the most important fragrance substances that belongs to the class of araliphatic alcohols. Phenylethyl alcohol is used frequently and in large amounts as a fragrance material. It is a popular component in rose-type compositions, but it is also used in other blossom notes. It is stable to alkali and, therefore, ideally suited for use in soap perfumes.
2. Pharmaceutic aid (antimicrobial). In flavors and perfumery (esp rose perfumes).
3. phenethyl alcohol is used to mask odor and also as a preservative.
4. In fragrance; antimicrobial agent; in organic synthesis; preservative, food additive
5. Phenylethyl alcohol is qualitatively and quantitatively one of the most important fragrance substances that belongs to the class of araliphatic alcohols. Phenylethyl alcohol is used frequently and in large amounts as a fragrance material. It is a popular component in rose-type compositions, but it is also used in other blossom notes. It is stable to alkali and, therefore, ideally suited for use in soap perfumes.
6. Pharmaceutic aid (antimicrobial). In flavors and perfumery (esp rose perfumes).
7. phenethyl alcohol is used to mask odor and also as a preservative.
8. In fragrance; antimicrobial agent; in organic synthesis; preservative, food additive

Production

Different sources of media describe the Production of 60-12-8 differently. You can refer to the following data:
1. Many syntheticmethods are known for preparing phenylethyl alcohol; the following are currently of industrial importance: 1) Friedel–Crafts reaction of benzene and ethylene oxide: In the presence of molar quantities of aluminum chloride, ethylene oxide reacts with benzene to give an addition product, which is hydrolyzed to phenylethyl alcohol: Formation of by-products, such as 1,2-diphenylethane, is largely avoided by using an excess of benzene at low temperature. Special purification procedures are required to obtain a pure product that is free of chlorine and suitable for use in perfumery. 2) Hydrogenation of styrene oxide: Excellent yields of phenylethyl alcohol are obtainedwhen styrene oxide is hydrogenated at low temperature, using Raney nickel as a catalyst and a small amount of sodium hydroxide.
2. Many syntheticmethods are known for preparing phenylethyl alcohol; the following are currently of industrial importance: 1) Friedel–Crafts reaction of benzene and ethylene oxide: In the presence of molar quantities of aluminum chloride, ethylene oxide reacts with benzene to give an addition product, which is hydrolyzed to phenylethyl alcohol: Formation of by-products, such as 1,2-diphenylethane, is largely avoided by using an excess of benzene at low temperature. Special purification procedures are required to obtain a pure product that is free of chlorine and suitable for use in perfumery. 2) Hydrogenation of styrene oxide: Excellent yields of phenylethyl alcohol are obtainedwhen styrene oxide is hydrogenated at low temperature, using Raney nickel as a catalyst and a small amount of sodium hydroxide.

Occurrence

Different sources of media describe the Occurrence of 60-12-8 differently. You can refer to the following data:
1. Reported found (as is or esterified) in several natural products: rose concentrate, rose absolute (60% or more) and rose distillation waters; also found in the essential oils of neroli, ylang-ylang, narcissus, hyacinth, lily, tea leaves, Michelia champaca, Pandamus odoratissimus, Congo and Réunion geranium, tobacco and other oils. It has been identified in wines. It has also been reported found in over 200 foods and beverages including apple, apricot, orange juice, orange peel, many berries, bilberry, cherry, grapefruit, peach, raisin, blackberry, guava, grapes, melon, papaya, asparagus, cabbage, leek, potato, rutabaga, tomato, Mentha oils, cinnamon, ginger, breads, butter, saffron, mustard, mango, many cheeses, butter, milk, cooked chicken, cognac, hop oil, beer, rum, whiskies, cider, sherry, cocoa, coffee, tea, nuts, oats, honey, soybean, coconut meat, avocado, olive, passion fruit, plum, beans, mushroom, starfruit, mango, tamarind, fruit brandies, fig, gin, rice, quince, radish, litchi, sukiyaki, calamus, licorice, buckwheat, watercress, elderberry fruit, kiwifruit, loquat, Tahiti and Bourbon vanilla, mountain papaya, endive, lemon balm, clary sage, shrimps, crab, Chinese quince, lamb’s lettuce, truffle and maté.
2. Reported found (as is or esterified) in several natural products: rose concentrate, rose absolute (60% or more) and rose distillation waters; also found in the essential oils of neroli, ylang-ylang, narcissus, hyacinth, lily, tea leaves, Michelia champaca, Pandamus odoratissimus, Congo and Réunion geranium, tobacco and other oils. It has been identified in wines. It has also been reported found in over 200 foods and beverages including apple, apricot, orange juice, orange peel, many berries, bilberry, cherry, grapefruit, peach, raisin, blackberry, guava, grapes, melon, papaya, asparagus, cabbage, leek, potato, rutabaga, tomato, Mentha oils, cinnamon, ginger, breads, butter, saffron, mustard, mango, many cheeses, butter, milk, cooked chicken, cognac, hop oil, beer, rum, whiskies, cider, sherry, cocoa, coffee, tea, nuts, oats, honey, soybean, coconut meat, avocado, olive, passion fruit, plum, beans, mushroom, starfruit, mango, tamarind, fruit brandies, fig, gin, rice, quince, radish, litchi, sukiyaki, calamus, licorice, buckwheat, watercress, elderberry fruit, kiwifruit, loquat, Tahiti and Bourbon vanilla, mountain papaya, endive, lemon balm, clary sage, shrimps, crab, Chinese quince, lamb’s lettuce, truffle and maté.

Production Methods

Different sources of media describe the Production Methods of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol is prepared by reduction of ethyl phenylacetate with sodium in absolute alcohol; by hydrogenation of phenylacetaldehyde in the presence of a nickel catalyst; or by addition of ethylene oxide or ethylene chlorohydrin to phenylmagnesium bromide, followed by hydrolysis. Phenylethyl alcohol also occurs naturally in a number of essential oils, especially rose oil.
2. Phenylethyl alcohol is prepared by reduction of ethyl phenylacetate with sodium in absolute alcohol; by hydrogenation of phenylacetaldehyde in the presence of a nickel catalyst; or by addition of ethylene oxide or ethylene chlorohydrin to phenylmagnesium bromide, followed by hydrolysis. Phenylethyl alcohol also occurs naturally in a number of essential oils, especially rose oil.

Preparation

Different sources of media describe the Preparation of 60-12-8 differently. You can refer to the following data:
1. From toluene, benzene or styrene.
2. From toluene, benzene or styrene.

Aroma threshold values

Different sources of media describe the Aroma threshold values of 60-12-8 differently. You can refer to the following data:
1. Detection: 0.015 ppb to 3.5 ppm; recognition: 1.2 ppm. Aroma characteristics at 1.0%: floral honey, yeasty bready, musty fresh and sweet.
2. Detection: 0.015 ppb to 3.5 ppm; recognition: 1.2 ppm. Aroma characteristics at 1.0%: floral honey, yeasty bready, musty fresh and sweet.

Taste threshold values

Different sources of media describe the Taste threshold values of 60-12-8 differently. You can refer to the following data:
1. Taste characteristics at 20 ppm: mushroom-like, rose floral, sweet, rosy, bready with honey nuances.
2. Taste characteristics at 20 ppm: mushroom-like, rose floral, sweet, rosy, bready with honey nuances.

Synthesis Reference(s)

Different sources of media describe the Synthesis Reference(s) of 60-12-8 differently. You can refer to the following data:
1. Chemistry Letters, 18, p. 619, 1989Journal of the American Chemical Society, 100, p. 4888, 1978 DOI: 10.1021/ja00483a042Tetrahedron Letters, 18, p. 3263, 1977 DOI: 10.1016/S0040-4039(01)83213-5
2. Chemistry Letters, 18, p. 619, 1989Journal of the American Chemical Society, 100, p. 4888, 1978 DOI: 10.1021/ja00483a042Tetrahedron Letters, 18, p. 3263, 1977 DOI: 10.1016/S0040-4039(01)83213-5

General Description

Different sources of media describe the General Description of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol, is a primary aromatic alcohol of high boiling point, having a characteristic rose-like odor. It presents organoleptic properties and impacts the quality of the wine, distilled beverages, and fermented foods. It shows its presence in fresh beer and is responsible for the rose-like odor of well-ripened cheese. It is commercially and industrially an important flavor and is a component of a variety of foodstuffs such as ice cream, gelatin, candy, pudding, chewing gum, and non-alcoholic beverages. It is formed by yeasts during fermentation of alcohols either by decomposition of L-phenylalanine or metabolism of sugar substrates.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
2. Phenylethyl alcohol, is a primary aromatic alcohol of high boiling point, having a characteristic rose-like odor. It presents organoleptic properties and impacts the quality of the wine, distilled beverages, and fermented foods. It shows its presence in fresh beer and is responsible for the rose-like odor of well-ripened cheese. It is commercially and industrially an important flavor and is a component of a variety of foodstuffs such as ice cream, gelatin, candy, pudding, chewing gum, and non-alcoholic beverages. It is formed by yeasts during fermentation of alcohols either by decomposition of L-phenylalanine or metabolism of sugar substrates.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Health Hazard

Different sources of media describe the Health Hazard of 60-12-8 differently. You can refer to the following data:
1. Phenylethanol is an irritant of the eyes and a teratogen in rats.
2. Phenylethanol is an irritant of the eyes and a teratogen in rats.

Pharmaceutical Applications

Different sources of media describe the Pharmaceutical Applications of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol is used as an antimicrobial preservative in nasal, ophthalmic, and otic formulations at 0.25–0.5% v/v concentration; it is generally used in combination with other preservatives.Phenylethyl alcohol has also been used on its own as an antimicrobial preservative at concentrations up to 1% v/v in topical preparations. At this concentration, mycoplasmas are inactivated within 20 minutes, although enveloped viruses are resistant.Phenylethyl alcohol is also used in flavors and as a perfumery component, especially in rose perfumes.
2. Phenylethyl alcohol is used as an antimicrobial preservative in nasal, ophthalmic, and otic formulations at 0.25–0.5% v/v concentration; it is generally used in combination with other preservatives.Phenylethyl alcohol has also been used on its own as an antimicrobial preservative at concentrations up to 1% v/v in topical preparations. At this concentration, mycoplasmas are inactivated within 20 minutes, although enveloped viruses are resistant.Phenylethyl alcohol is also used in flavors and as a perfumery component, especially in rose perfumes.

Safety Profile

Different sources of media describe the Safety Profile of 60-12-8 differently. You can refer to the following data:
1. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Experimental teratogenic effects. Other experimental reproductive effects. Causes severe central nervous system injury to experimental animals. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fEe, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes
2. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Experimental teratogenic effects. Other experimental reproductive effects. Causes severe central nervous system injury to experimental animals. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fEe, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes

Safety

Different sources of media describe the Safety of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol is generally regarded as a nontoxic and nonirritant material. However, at the concentration used to preserve eye-drops (about 0.5% v/v) or above, eye irritation may occur. LD50 (rabbit, skin): 0.79 g/kg LD50 (rat, oral): 1.79 g/kg
2. Phenylethyl alcohol is generally regarded as a nontoxic and nonirritant material. However, at the concentration used to preserve eye-drops (about 0.5% v/v) or above, eye irritation may occur. LD50 (rabbit, skin): 0.79 g/kg LD50 (rat, oral): 1.79 g/kg

Carcinogenicity

Different sources of media describe the Carcinogenicity of 60-12-8 differently. You can refer to the following data:
1. Phenylethanol was not mutagenic in bacterial assays, nor did it increase the number of sister chromatid exchanges in human lymphocytes.
2. Phenylethanol was not mutagenic in bacterial assays, nor did it increase the number of sister chromatid exchanges in human lymphocytes.

Metabolism

Different sources of media describe the Metabolism of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol is oxidized almost entirely to the corresponding acid (Williams. 1959).
2. Phenylethyl alcohol is oxidized almost entirely to the corresponding acid (Williams. 1959).

storage

Different sources of media describe the storage of 60-12-8 differently. You can refer to the following data:
1. Phenylethyl alcohol is stable in bulk, but is volatile and sensitive to light and oxidizing agents. It is reasonably stable in both acidic and alkaline solutions. Aqueous solutions may be sterilized by autoclaving. If stored in low-density polyethylene containers, phenylethyl alcohol may be absorbed by the containers. Losses to polypropylene containers have been reported to be insignificant over 12 weeks at 30°C. Sorption to rubber closures is generally small. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.
2. Phenylethyl alcohol is stable in bulk, but is volatile and sensitive to light and oxidizing agents. It is reasonably stable in both acidic and alkaline solutions. Aqueous solutions may be sterilized by autoclaving. If stored in low-density polyethylene containers, phenylethyl alcohol may be absorbed by the containers. Losses to polypropylene containers have been reported to be insignificant over 12 weeks at 30°C. Sorption to rubber closures is generally small. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

Purification Methods

Different sources of media describe the Purification Methods of 60-12-8 differently. You can refer to the following data:
1. Purify the ethanol by shaking it with a solution of ferrous sulfate, and the alcohol layer is washed with distilled water and fractionally distilled. [Beilstein 6 IV 3067.]
2. Purify the ethanol by shaking it with a solution of ferrous sulfate, and the alcohol layer is washed with distilled water and fractionally distilled. [Beilstein 6 IV 3067.]

Incompatibilities

Different sources of media describe the Incompatibilities of 60-12-8 differently. You can refer to the following data:
1. Incompatible with oxidizing agents and protein, e.g. serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates.
2. Incompatible with oxidizing agents and protein, e.g. serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates.

Regulatory Status

Different sources of media describe the Regulatory Status of 60-12-8 differently. You can refer to the following data:
1. Included in the FDA Inactive Ingredients Database (nasal, ophthalmic, and otic preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
2. Included in the FDA Inactive Ingredients Database (nasal, ophthalmic, and otic preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

InChI:InChI=1/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2

Synthetic route

styrene oxide (96-09-3) → 2-phenylethanol (60-12-8)

Conditions	Yield
With morpholine-borane; boron trifluoride diethyl etherate In diethyl ether for 2h; Product distribution; Ambient temperature;	100%
With ammonium formate; palladium on activated charcoal In methanol for 2h; Heating;	100%
With hydrogen In methanol at 25℃; under 750.075 Torr; Reagent/catalyst; Flow reactor; regioselective reaction;	100%

trimethyl(phenethyloxy)silane (14629-58-4) → 2-phenylethanol (60-12-8)

Conditions	Yield
With Dowex 1-X8 In ethanol for 8h; Ambient temperature;	100%
With bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 0.0166667h;	98%
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0833333h; Green chemistry;	98%

1-tert-butyldimethylsilyloxy-2-phenylethane (78926-09-7) → 2-phenylethanol (60-12-8)

Conditions	Yield
With iron(III) chloride In methanol at 23℃; for 3.5h;	100%
With water; scandium tris(trifluoromethanesulfonate) In acetonitrile for 1h; Ambient temperature;	98%
sulfonic acid functionalized nanoporous silica In methanol at 35℃; for 1.5h;	98%

acetophenone (98-86-2) → 2-phenylethanol (60-12-8)

Conditions	Yield
With potassium tert-butylate; hydrogen In ethanol at 40℃; under 7600.51 Torr; for 19h; Solvent; Autoclave; Inert atmosphere;	100%
With magnesium sulfate In tetrahydrofuran; dichloromethane	92%
With magnesium sulfate In tetrahydrofuran; dichloromethane	92%

acetic acid phenethyl ester (103-45-7) → 2-phenylethanol (60-12-8) + phenol (108-95-2)

Conditions	Yield
With phosphate buffer; Phenyl acetate In diethyl ether for 2.75h; Ambient temperature; pig liver acetone powder;	A 18% B 100%

benzeneacetic acid methyl ester (101-41-7) → 2-phenylethanol (60-12-8)

Conditions	Yield
With lithium aluminium tetrahydride; silica gel In hexane for 3h; Heating;	100%
With methanol; sodium tetrahydroborate In diethyl ether at 20℃; for 38h; Reduction;	96%
With sodium tetrahydroborate In diethylene glycol dimethyl ether at 104℃;	95%

1-(triethylsiloxy)-2-phenylethane (14629-62-0) → 2-phenylethanol (60-12-8)

Conditions	Yield
With iron(III) chloride In methanol at 23℃; for 0.0833333h;	100%
With methanol; trimethylsilyl bromide at 20℃; for 0.166667h; chemoselective reaction;	98%
With Selectfluor In acetonitrile at 150℃; for 0.05h; Microwave irradiation;	82%
With iron(III) p-toluenesulfonate hexahydrate In methanol at 20℃; for 0.333333h;	80%
With hydrogenchloride In methanol at 20℃; for 16h;

C24H20O3 (1093198-50-5) → 2-phenylethanol (60-12-8)

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate In ethanol; benzene at 20℃; for 0.3h;	100%

allyl 2-phenylethyl carbonate (501014-38-6) → 2-phenylethanol (60-12-8)

Conditions	Yield
[RuCp(η3-C3H5)(QA)]PF6, QA=quinaldic acid In methanol at 30℃; for 0.5h;	99%
With Fe3O4@SiO2-[(4-(5-O3Si-pentylcarbamoyl)-2-pyridinecarboxylato)CpRu(η3-C3H5)]PF6 In methanol at 30℃; for 2h; Inert atmosphere; chemoselective reaction;	99.9%
[RuCp(η3-C3H5)(QA)]PF6, QA=quinaldic acid In methanol at 30℃; for 0.5h; Product distribution; Further Variations:; Solvents;	99 % Spectr.

ethylbenzene (100-41-4) → 4-Ethylphenol (123-07-9) + 1-Phenylethanol (98-85-1, 13323-81-4) + 2-phenylethanol (60-12-8)

Conditions	Yield
With rabbit liver microsomal cytochrome P-450 In water at 25℃; for 12h;	A 0.13% B 99.8% C 0.08%

styrene oxide (96-09-3) → 1-Phenylethanol (98-85-1, 13323-81-4) + 2-phenylethanol (60-12-8)

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; hydrogen In toluene at 75℃; under 37503.8 Torr; for 24h; Catalytic behavior; Pressure; Temperature; Reagent/catalyst; regioselective reaction;	A 99% B n/a
With lithium triethylborohydride In tetrahydrofuran at 0℃; for 0.0833333h; Product distribution;	A 97% B 3%
With Li(1+)*C12H28AlO3(1-) In tetrahydrofuran; hexane at 0℃; for 0.17h; Yields of byproduct given;	A 95% B n/a

phenylacetaldehyde (122-78-1) → 2-phenylethanol (60-12-8)

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; tri-n-butyl-tin hydride for 2h; Product distribution; Ambient temperature; different aldehydes, reagents, reaction temperature and time;	99%
With N,N,N,N,N,N-hexamethylphosphoric triamide; tri-n-butyl-tin hydride for 2h; Ambient temperature;	99%
With hydrogen In water at 60℃; under 22502.3 Torr; for 0.00611111h; Flow reactor; Green chemistry; chemoselective reaction;	99%

Ethyl 2-phenylethanoate (101-97-3) → 2-phenylethanol (60-12-8)

Conditions	Yield
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 5h; Glovebox; Autoclave;	99%
	95%
With lithium borohydride In diethyl ether; toluene at 100℃; for 1h;	92%

2-(2-propenyloxy)ethylbenzene (14289-65-7) → 2-phenylethanol (60-12-8)

Conditions	Yield
With quinoline-2-carboxylic acid; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate In methanol at 30℃; for 3h;	99%
[RuCp(η3-C3H5)(QA)]PF6, QA=quinaldic acid In methanol at 30℃; for 3h;	99%
quinoline-2-carboxylic acid; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate In methanol; dichloromethane at 30℃; for 0.5h; Conversion of starting material;	99%

benzyl 2-phenylacetate (102-16-9) → 2-phenylethanol (60-12-8)

Conditions	Yield
With tri-n-butyl-tin hydride; hafnium tetrachloride In tetrahydrofuran at -20℃; for 3h; Inert atmosphere;	99%
With (Ppyz)Zr(BH4)2Cl2 In diethyl ether for 8h; Heating;	92%
With phenylsilane; potassium tert-butylate; water; sodium triethylborohydride; cobalt(II) chloride In 1,4-dioxane; toluene at 60℃; for 15h; Inert atmosphere; Glovebox; Schlenk technique;	84%

potassium trifluoro(phenethyl)borate → 2-phenylethanol (60-12-8)

Conditions	Yield
With Oxone; water In acetone at 20℃; for 0.0333333h;	99%

phenylacetyl chloride (103-80-0) → 2-phenylethanol (60-12-8)

Conditions	Yield
With zinc(II) tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In diethyl ether at 0℃; for 0.5h;	98%
With methyltriphenylphosphonium tetrahydroborate In dichloromethane Reduction;	98%
With Zr(BH4)2Cl2(dabco)2 In tetrahydrofuran for 1.2h; Heating;	98%

2-(2-phenylethoxy)tetrahydro-2H-pyran (1927-61-3) → 2-phenylethanol (60-12-8)

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In methanol for 0.05h; Heating;	98%
With dimethylbromosulphonium bromide In methanol; dichloromethane at 20℃; for 0.416667h;	97%
With trichloroisocyanuric acid In methanol at 20℃; for 5h;	96%

isopropyl phenylacetate (4861-85-2) → 2-phenylethanol (60-12-8)

Conditions	Yield
Stage #1: isopropyl phenylacetate With diethylzinc; lithium chloride In tetrahydrofuran; hexane at 20℃; for 6h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; hexane; water at 20℃; for 8h; Catalytic behavior; Concentration; Time; Inert atmosphere; chemoselective reaction;	98%
With phenylsilane; potassium tert-butylate; water; sodium triethylborohydride; cobalt(II) chloride In 1,4-dioxane; toluene at 60℃; for 15h; Inert atmosphere; Glovebox; Schlenk technique;	93%
Stage #1: isopropyl phenylacetate With diethoxymethylane; zinc diacetate In tetrahydrofuran at 65℃; for 24h; Inert atmosphere; Stage #2: With methanol; potassium hydroxide chemoselective reaction;	98 %Chromat.
Stage #1: isopropyl phenylacetate With iron (II) stearate; ethylenediamine In toluene at 20℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: In toluene at 100℃; for 20h; Inert atmosphere; Schlenk technique;	71 %Chromat.
With 1,1'-methylene-bis(3-benzyl-1H-imidazol-3-ium) diiodide; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium tert-butylate; hydrogen In 1,4-dioxane at 100℃; under 37503.8 Torr; for 6h;	50 %Chromat.

allyl 2-phenylethyl carbonate (501014-38-6) + 2-propanethiol (75-33-2) → allylisopropyl sulfide (50996-72-0) + carbon dioxide (124-38-9) + 2-phenylethanol (60-12-8)

Conditions	Yield
With [Bu4N][Fe(CO)3(NO)]; tris(2,4,6-trimethylphenyl)phosphine In ethanol at 40℃; Inert atmosphere;	A n/a B n/a C 98%

(2-phenylethyl)boronic acid (34420-17-2) → 2-phenylethanol (60-12-8)

Conditions	Yield
With pyrene-1,6-dione; oxygen; isopropyl alcohol at 20℃; under 760.051 Torr; for 40h; Irradiation; Green chemistry;	98%
With rose bengal; triethylamine In ethanol at 25℃; for 12h; Schlenk technique; Irradiation;	97%
With 2,5-dimethylfuran; zinc(II) phthalocyanine; oxygen In tetrahydrofuran at 25℃; under 760.051 Torr; for 2h; Time; Irradiation; Sealed tube; Schlenk technique;	95%

(+/-)-2-(3-cyclohexenyl)ethanol (18240-10-3) → 2-phenylethanol (60-12-8)

Conditions	Yield
With hydrogen at 250℃; under 750.075 Torr; Reagent/catalyst; Green chemistry;	97.92%

phenylacetic acid (103-82-2) → 2-phenylethanol (60-12-8)

Conditions	Yield
With [Zn(BH4)2(py)] In tetrahydrofuran for 1.5h; Heating;	97%
With zinc(II) tetrahydroborate In tetrahydrofuran for 3h; Heating;	95%
With borane-THF In tetrahydrofuran for 3.25h; Inert atmosphere;	95%

2-phenylethyl chloride (622-24-2) → 2-phenylethanol (60-12-8)

Conditions	Yield
With iron(III) sulfate; water In toluene at 110℃; for 1h; Ionic liquid;	97%
With sodium carbonate at 160 - 165℃;
With sodium carbonate at 175℃;

phenylacetic anhydride (1555-80-2) → phenylacetic acid (103-82-2) + 2-phenylethanol (60-12-8)

Conditions	Yield
With methanol; sodium tetrahydroborate In tetrahydrofuran for 1h; Ambient temperature;	A 94% B 97%

N-(4-Phenethyloxymethyl-phenyl)-acetamide (128702-35-2) → 2-phenylethanol (60-12-8)

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone	97%

(2-(methoxymethoxy)ethyl)benzene (54673-12-0) → 2-phenylethanol (60-12-8)

Conditions	Yield
phosphotungstic acid In ethanol for 3h; Heating;	97%
With 1-methylimidazole hydrogen sulfate at 120℃; for 0.025h; Microwave irradiation; chemoselective reaction;	95%
With 1-thiopropane; zinc dibromide In dichloromethane at 20℃; for 0.1h; Inert atmosphere;	90%

phenylacetylene (536-74-3) → 2-phenylethanol (60-12-8)

Conditions	Yield
With [2,2]bipyridinyl; formic acid; (η5-cyclopentadienyl) (η6-naphthalene)ruthenium hexafluorophosphate; water In tetrahydrofuran at 55℃; for 48h;	97%
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); Ru(Cp)(PPh2PytBu)2(MeCN)PF6; water In isopropyl alcohol at 70℃; for 48h; Concentration; Reagent/catalyst; Inert atmosphere; regioselective reaction;	90%
With formic acid; F6P(1-)*C16H22N3Ru(1+); water In 1-methyl-pyrrolidin-2-one at 25℃; for 48h; Inert atmosphere; Sealed tube;	83%
Multi-step reaction with 2 steps 1: cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; [2,2]bipyridinyl; formic acid / water; 1-methyl-pyrrolidin-2-one / 24 h / 25 °C / Inert atmosphere; Sealed tube 2: N1,N1-dimethyl-N2-(pyridin-2-ylmethylene)ethane-1,2-diamine; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; formic acid; water / 1-methyl-pyrrolidin-2-one / 24 h / 25 °C / Inert atmosphere; Sealed tube View Scheme

acetic acid phenethyl ester (103-45-7) → 2-phenylethanol (60-12-8)

Conditions	Yield
With water at 20℃; for 0.166667h;	96%
With methanol; potassium permanganate at 25℃; chemoselective reaction;	92%
With 2,2-dibutyl-1,3,2-dioxastannane; cesium fluoride In N,N-dimethyl-formamide at 20℃; for 0.5h;	85%

2-phenylethanol (60-12-8) → 2-phenethyl iodide (17376-04-4)

Conditions	Yield
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether at 0℃; for 1h;	100%
With trimethylsilylphosphate; sodium iodide for 10h; Ambient temperature;	98%
With N-iodosaccharine; triphenylphosphine In dichloromethane at 20℃; for 0.5h;	95%

2-phenylethanol (60-12-8) + acetic anhydride (108-24-7) → acetic acid phenethyl ester (103-45-7)

Conditions	Yield
With magnesium(II) perchlorate at 20℃; for 0.25h;	100%
Stage #1: acetic anhydride With molybdenium(VI) dioxodichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-phenylethanol In dichloromethane at 20℃; for 0.1h;	100%
With boron trifluoride diethyl etherate In ethyl acetate for 0.00138889h;	100%

2-phenylethanol (60-12-8) + trichloroacetonitrile (545-06-2) → β-phenylethyl trichloroacetimidate (99421-73-5)

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane	100%
With sodium
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃;

2-phenylethanol (60-12-8) + benzoic acid (65-85-0) → 2-Phenylethyl benzoate (94-47-3)

Conditions	Yield
With TiO(acac)2 In xylene for 15h; Heating;	100%
With iron(III)-acetylacetonate In 5,5-dimethyl-1,3-cyclohexadiene for 15h; Inert atmosphere; Reflux;	97%
With 4-nitro-diphenylammonium triflate In toluene at 80℃; for 30h;	95%

2-phenylethanol (60-12-8) + N-(tert-butyloxycarbonyl)(2-trimethylsilylethyl)sulfonamide (145387-82-2) → tert-Butyl phenethyl<<2-(trimethylsilyl)ethyl>sulfonyl>carbamate

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0℃; for 0.0833333h;	100%

2-phenylethanol (60-12-8) → phenylacetic acid (103-82-2)

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite In acetonitrile at 35℃; pH 6.7;	100%
With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; water; acetonitrile at 35℃; pH=6.7; Green chemistry;	100%
With oxygen; sodium hydroxide In water at 90℃; for 18h; Catalytic behavior;	100%

carbon disulfide (75-15-0) + 2-phenylethanol (60-12-8) + methyl iodide (74-88-4) → S-methyl O-phenylethyl carbonodithioate (70061-62-0)

Conditions	Yield
Stage #1: 2-phenylethanol With sodium hydride In tetrahydrofuran; mineral oil for 0.333333h; Stage #2: carbon disulfide In tetrahydrofuran; mineral oil at 20℃; for 0.333333h; Stage #3: methyl iodide In tetrahydrofuran; mineral oil for 0.333333h;	100%
Stage #1: carbon disulfide; 2-phenylethanol With 1H-imidazole; sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 0.5h;	95%
With sodium hydroxide; tetrabutylammomium bromide In water	75%
Yield given. Multistep reaction;

2-phenylethanol (60-12-8) + pivaloyl chloride (3282-30-2) → 2-phenethyl pivalate (67662-96-8)

Conditions	Yield
at 20℃; for 0.0833333h; Neat (no solvent);	100%
With lanthanum(III) nitrate at 20℃; for 0.166667h;	96%
With pyridine In dichloromethane at 25℃; for 5h; Acylation;
With picoline In dichloromethane for 1h; Reflux;
Stage #1: 2-phenylethanol With bis(cyclopentadienyl)titanium dichloride; manganese; diiodomethane In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere; Stage #2: pivaloyl chloride In tetrahydrofuran at 20℃; for 1.5h; Solvent; Inert atmosphere;

3,4-dihydro-2H-pyran (110-87-2) + 2-phenylethanol (60-12-8) → 2-(2-phenylethoxy)tetrahydro-2H-pyran (1927-61-3)

Conditions	Yield
With H6P2W18O62 In toluene at 20℃; for 2h;	100%
With phosphotungstic acid In toluene at 20℃; for 1h;	100%
With iron(III) sulfate at 20℃; for 1h;	98%

2-phenylethanol (60-12-8) + 4-carboxymethoxy-benzoic acid (19360-67-9) → 4-phenethyloxycarbonylmethoxy-benzoic acid

Conditions	Yield
With [Cl(C6F13C2H4)2SnOSn(C2H4C6F13)2Cl]2 In various solvent(s) at 150℃; for 16h;	100%

2-phenylethanol (60-12-8) + benzyl alcohol (100-51-6) → (2-(benzyloxy)ethyl)benzene (54894-37-0)

Conditions	Yield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I) at 150℃; for 0.5h; Kinetics; Inert atmosphere; Microwave irradiation;	100%
With (triphenylphosphine)gold(I) chloride at 150℃; for 1.5h; Microwave irradiation; Green chemistry;	96%
With n-butyllithium; 2,3,5,6-tetrafluoro-1,4-benzoquinone; chloro-diphenylphosphine In dichloromethane at 20℃; for 3h; Product distribution; Further Variations:; Reagents;	72%

butanoic acid anhydride (106-31-0) + 2-phenylethanol (60-12-8) → phenethyl butyrate (103-52-6)

Conditions	Yield
Stage #1: butanoic acid anhydride With molybdenium(VI) dioxodichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-phenylethanol In dichloromethane at 20℃; for 0.15h;	100%
With iron(III) p-toluenesulfonate hexahydrate In neat (no solvent) at 20℃; for 1h;	85%

di-n-butyloxymethane (2568-90-3) + 2-phenylethanol (60-12-8) → formaldehyde-(butyl-phenethyl-acetal) (92101-62-7)

Conditions	Yield
With Nafion-H SAC-13 silica nanocomposite at 100℃;	100%

2-phenylethanol (60-12-8) + chloro-diphenylphosphine (1079-66-9) → 2-phenylethyl diphenylphosphinite (849604-79-1)

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h;	100%
With n-butyllithium In tetrahydrofuran at 0℃; for 1h;
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #1: 2-phenylethanol With n-butyllithium In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Schlenk technique; Stage #2: chloro-diphenylphosphine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique;

2-phenylethanol (60-12-8) + caffeic acid (331-39-5) → caffeic acid phenethylester

Conditions	Yield
at 50℃; for 120h;	100%
Stage #1: 2-phenylethanol; caffeic acid at 20℃; for 0.25h; Molecular sieve; Ionic liquid; Inert atmosphere; Stage #2: With Tocopherol at 130℃; under 760.051 Torr; for 0.15h; Solvent; Reagent/catalyst; Temperature; Molecular sieve; Ionic liquid; Inert atmosphere; Microwave irradiation;	95%
In benzene for 84h; Heating; Dean-Stark trap;	40%

2-phenylethanol (60-12-8) + triethylammonium dimethyl boranophosphate → phosphorous acid dimethyl ester phenethyl ester; compound with borane

Conditions	Yield
With 2,6-dimethylpyridine; diazaphospholidinium-based reagent In acetonitrile at 20℃; for 0.166667h;	100%

2-phenylethanol (60-12-8) + tert-butylamine (75-64-9) → 2-methyl-N-phenethylpropan-2-amine (24070-10-8)

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; 3 A molecular sieve; potassium carbonate; [Ru(p-cumene)Cl2]2 In toluene at 110℃; for 24h; Product distribution; Further Variations:; Catalysts;	100%
With 1,1'-bis(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium carbonate In toluene at 20℃; for 24.1667h; Inert atmosphere; Molecular sieve; Reflux;	88%
With C61H45N3OP2RuS; potassium hydroxide In toluene at 110℃; for 12h; Schlenk technique;	79%
Stage #1: 2-phenylethanol With 1,1'-bis-(diphenylphosphino)ferrocene; [RuCl2(p-cymene)(3-INC5H4)] In toluene for 0.166667h; Reflux; Stage #2: tert-butylamine In toluene; acetonitrile for 24h; Reagent/catalyst; Reflux;
Stage #1: 2-phenylethanol With [bis((μ-chloro)chloro(η6-phenylacetic acid)ruthenium(II))] In toluene at 110℃; for 0.166667h; Reflux; Stage #2: tert-butylamine In toluene; acetonitrile at 110℃; for 24h; Catalytic behavior; Reagent/catalyst; Time; Reflux;

2-phenylethanol (60-12-8) + ethenyltrimethylsilane (754-05-2) → ethene (74-85-1) + trimethyl(phenethyloxy)silane (14629-58-4)

Conditions	Yield
hydrogenchloride; chlorobis(ethylene)rhodium(I) dimer In 1,4-dioxane; chloroform at 20℃; for 2h; Product distribution / selectivity;	A n/a B 100%
chlorobis(cyclooctene)rhodium(I) dimer In toluene at 70℃; for 3h; Product distribution / selectivity;	A n/a B 100%
hydrogenchloride; chlorobis(cyclooctene)rhodium(I) dimer In 1,4-dioxane; chloroform at 20℃; for 2h; Product distribution / selectivity;	A n/a B 96%

2-phenylethanol (60-12-8) → acetic acid phenethyl ester (103-45-7)

Conditions	Yield
Stage #1: acetic anhydride; TiO(OTf)2 In dichloromethane at 20℃; for 0.5h; Stage #2: 2-phenylethanol In dichloromethane at 20℃; for 0.3h; Product distribution / selectivity;	100%
Stage #1: acetic anhydride; bis(tetrahydrofurane)oxovanadium(IV) dichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-phenylethanol In dichloromethane at 20℃; for 12h; Product distribution / selectivity;	99%
Stage #1: acetic anhydride; bis(acetylacetonato)dioxidomolybdenum(VI) In dichloromethane at 20℃; for 0.5h; Stage #2: 2-phenylethanol In dichloromethane at 20℃; for 16h; Product distribution / selectivity;	98%

4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline (286371-46-8) + bis(trichloromethyl) carbonate (32315-10-9) + 2-phenylethanol (60-12-8) + sodium hydrogencarbonate (144-55-8) → phenethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate

Conditions	Yield
With triethylamine In methanol; dichloromethane; chloroform; toluene	100%

2-phenylethanol (60-12-8) → 4-methoxy-3-phenethyloxynitrobenzene

Conditions	Yield
	100%

hexan-1-amine (111-26-2) + 2-phenylethanol (60-12-8) → N-hexyl-2-phenylacetamide (10264-30-9)

Conditions	Yield
With cyclooctadiene ruthenium(II) dichloride; potassium tert-butylate; 1,3-diisopropyl-1H-imidazol-3-ium chloride; tricyclopentylphosphonium tetrafluoroborate In toluene for 24h; Inert atmosphere; Reflux;	100%
With dichloro(1,5-cyclooctadiene)ruthenium(II); potassium tert-butylate; 1,3-diisopropyl-1H-imidazol-3-ium chloride; tricyclopentylphosphonium tetrafluoroborate In toluene at 110℃; for 24h; Inert atmosphere;	100%
With pyridine; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; sodium hydride; 1,3-di(propan-2-yl)-1H-imidazol-3-ium bromide In toluene for 36h; Inert atmosphere; Reflux;	98%

Upstream product

• 8007-01-0 Rose Oil 
• 140-29-4 Benzeneacetonitrile 
• 8000-46-2 Geranium oil 
• 8014-95-7 SULFURIC ACID 
• 101-97-3 Ethyl phenylacetate 
• 96-09-3 Styrene oxide 
• 100-44-7 Benzyl chloride 
• 108-86-1 Bromobenzene 
• 1333-74-0 Hydrogen 
• 7440-02-0 Nickel 
• 7775-09-9 Sodium chlorate 
• 8016-38-4 FEMA 2771 

Downstream Products

• 56718-71-9 p-(2-Methoxyethyl) phenol 
• 56781-71-9 4-(2-Methoxyethyl)Phenol 
• 103-45-7 Phenethyl acetate 
• 56718-70-8 [[p-(2-methoxyethyl)phenoxy]methyl]oxirane 
• 104-62-1 PHENETHYL FORMATE 
• 103-48-0 Phenethyl isobutyrate 
• 103-52-6 Phenethyl butyrate 
• 103-53-7 Phenethyl cinnamate 
• 103-63-9 (2-Bromoethyl)benzene 
• 118-58-1 Benzyl salicylate 
• 122-70-3 2-PHENYLETHYL PROPIONATE 
• 122-78-1 Phenylacetaldehyde 
• 133-18-6 FEMA 2859 
• 140-26-1 FEMA 2871 
• 8007-01-0 Rose Oil 
• 102-20-5 Phenethyl phenylacetate 
• 121-75-5 Malathion 
• 141-05-9 Diethyl maleate 
• 24817-51-4 FEMA 3632 
• 3558-60-9 (2-Methoxyethyl)benzene 
• 37350-58-6 Metoprolol 
• 508-75-8 CONVALLATOXIN 
• 5457-70-5 FEMA 3222 
• 87-22-9 PHENETHYL SALICYLATE 
• 93-92-5 Styralyl acetate 
• 95-82-9 2,5-Dichloroaniline 

Recommend Products

• 74121-91-8  (2-Hydroxyethyl)phenylethyl ether 
• 75-21-8  oxirane 
• 1623-99-0  phenyl sodium 
• 103-29-7  1,1'-(1,2-ethanediyl)bisbenzene 
• 71-43-2  benzene 
• 7681-84-7  tetrahydrofuran-2-carbaldehyde 
• 108876-10-4  2-phenethyloxy-tetrahydro-furan-2-carbonitrile 
• 108734-03-8  4,5-dihydro-furan-2-carbonitrile 
• 14371-10-9  (E)-3-phenylpropenal 
• 96-09-3  styrene oxide 
• 98-85-1  1-Phenylethanol 
• 71653-43-5  2-phenylethyl nicotinate 
• 59-67-6  nicotinic acid 
• 57913-41-4  2-phenylethyl chloroformate