3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-N-[3-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-1-(3,3 -dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-

Base Information

Chemical Name:3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-N-[3-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-1-(3,3 -dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-
CAS No.:528883-28-5
Molecular Formula:C30H34N6O5
Molecular Weight:558.637
Hs Code.:

3H-1,3,4-Benzotriazepine-3-acetamide,
5-cyclohexyl-N-[3-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-1-(3,3
-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-

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Chemical Property of 3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-N-[3-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-1-(3,3 -dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-

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Technology Process of 3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-N-[3-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-1-(3,3 -dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-

There total 7 articles about 3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-N-[3-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)phenyl]-1-(3,3 -dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 528883-29-6
3-(3-amino-phenyl)-2H-[1,2,4]oxadiazol-5-one trifluoroacetic acid salt

: 528883-28-5
2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-^1,2,4oxadiazol-3-yl)-phenyl)-acetamide

Guidance literature:: (5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2h;

3-(3-amino-phenyl)-2H-[1,2,4]oxadiazol-5-one trifluoroacetic acid salt; With triethylamine; In DMF (N,N-dimethyl-formamide); for 16h;

Reference yield: 22.0%

: 528882-12-4
(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid

: 503469-36-1
3-(3-amino-phenyl)-2H-[1,2,4]oxadiazol-5-one

: 528883-28-5
2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-^1,2,4oxadiazol-3-yl)-phenyl)-acetamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm070139l

Reference yield:

: 528882-09-9
(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

: 528883-28-5
2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-^1,2,4oxadiazol-3-yl)-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 84 percent / dimethylformamide / 2 h / 20 °C

2.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

3.1: 22 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

With dmap; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l