2-Thiazolecarboxylic acid, 4-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Base Information

Chemical Name:2-Thiazolecarboxylic acid, 4-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-
CAS No.:528884-39-1
Molecular Formula:C32H35N5O5S
Molecular Weight:601.726
Hs Code.:

2-Thiazolecarboxylic acid,
4-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,
3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Synonyms:

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Chemical Property of 2-Thiazolecarboxylic acid, 4-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

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Technology Process of 2-Thiazolecarboxylic acid, 4-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

There total 10 articles about 2-Thiazolecarboxylic acid, 4-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 942232-14-6
C₃₄H₃₉N₅O₅S

: 528884-39-1
4-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-thiazole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 21h;
DOI:10.1021/jm070139l

Reference yield:

: 53101-05-6
4-(3-nitro-phenyl)-thiazole-2-carboxylic acid ethyl ester

: 528884-39-1
4-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-thiazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / SnCl₂*H₂O / ethyl acetate / 3 h / Heating

2: 53 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

3: 90 percent / aq. NaOH / ethanol / 21 h / 20 °C

With dmap; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l

Reference yield:

: 528882-09-9
(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

: 528884-39-1
4-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-thiazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 84 percent / dimethylformamide / 2 h / 20 °C

2.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

3.1: 53 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

4.1: 90 percent / aq. NaOH / ethanol / 21 h / 20 °C

With dmap; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l