3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-N-[3-(2,5-dihydro-5-oxo-1,2,4- oxadiazol-3-yl)phenyl]-1,2-dihydro-2-oxo-

Base Information

Chemical Name:3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-N-[3-(2,5-dihydro-5-oxo-1,2,4- oxadiazol-3-yl)phenyl]-1,2-dihydro-2-oxo-
CAS No.:528884-77-7
Molecular Formula:C31H34N6O5
Molecular Weight:570.648
Hs Code.:

3H-1,3,4-Benzotriazepine-3-acetamide,
5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-N-[3-(2,5-dihydro-5-oxo-1,2,4-
oxadiazol-3-yl)phenyl]-1,2-dihydro-2-oxo-

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Chemical Property of 3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-N-[3-(2,5-dihydro-5-oxo-1,2,4- oxadiazol-3-yl)phenyl]-1,2-dihydro-2-oxo-

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Technology Process of 3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-N-[3-(2,5-dihydro-5-oxo-1,2,4- oxadiazol-3-yl)phenyl]-1,2-dihydro-2-oxo-

There total 7 articles about 3H-1,3,4-Benzotriazepine-3-acetamide, 5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-N-[3-(2,5-dihydro-5-oxo-1,2,4- oxadiazol-3-yl)phenyl]-1,2-dihydro-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 528882-09-9
(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

: 528884-77-7
2-(5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 54 percent / dimethylformamide / 2 h / 20 °C

2.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

3.1: oxalyl chloride / DMF / CH₂Cl₂ / 2.5 h / 20 °C

4.1: 2.5 g / Et₃N / CH₂Cl₂ / 16 h / 20 °C

With sodium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; DMF; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l

Reference yield:

: 929710-14-5
[5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid ethyl ester

: 528884-77-7
2-(5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

2: oxalyl chloride / DMF / CH₂Cl₂ / 2.5 h / 20 °C

3: 2.5 g / Et₃N / CH₂Cl₂ / 16 h / 20 °C

With sodium hydroxide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane;
DOI:10.1021/jm070139l

Reference yield:

: 528882-08-8
(N'-((2-amino-phenyl)-cyclohexyl-methylene)-hydrazino)acetic acid ethyl ester

: 528884-77-7
2-(5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / NEt₃ / CH₂Cl₂ / 1 h / 0 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 54 percent / dimethylformamide / 2 h / 20 °C

3.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

4.1: oxalyl chloride / DMF / CH₂Cl₂ / 2.5 h / 20 °C

5.1: 2.5 g / Et₃N / CH₂Cl₂ / 16 h / 20 °C

With sodium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; DMF; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l