2-Furancarboxylic acid, 5-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Base Information

• Chemical Name: 2-Furancarboxylic acid, 5-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-
• CAS No.: 528885-24-7
• Molecular Formula: C33H36N4O6
• Molecular Weight: 584.672
• Mol file: 528885-24-7.mol

Synonyms:

Chemical Property of 2-Furancarboxylic acid, 5-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Furancarboxylic acid, 5-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

There total 11 articles about 2-Furancarboxylic acid, 5-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C34H38N4O6 (942232-15-7) → 5-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-furan-2-carboxylic acid (528885-24-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm070139l

Reference yield:

(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester (528882-09-9) → 5-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-furan-2-carboxylic acid (528885-24-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 84 percent / dimethylformamide / 2 h / 20 °C

2.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

3.1: 70 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

4.1: 91 percent / aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm070139l

Reference yield:

(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid (528882-12-4) → 5-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-furan-2-carboxylic acid (528885-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

2: 91 percent / aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm070139l

upstream raw materials:

C₃₄H₃₈N₄O₆

(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid

(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

Downstream raw materials:

5-(3-{2-[5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl]-acetylamino}-phenyl)-furan-2-carboxylic acid N-methyl-D-glucamine salt