1-(3-Methylphenyl)piperazine dihydrochloride hydrate

Base Information

Chemical Name:1-(3-Methylphenyl)piperazine dihydrochloride hydrate
CAS No.:13078-13-2
Molecular Formula:C11H16 N2 . 2 Cl H
Molecular Weight:249.183
Hs Code.:2933599090
UNII:4V85S2L7B9
NSC Number:150848,71662
Mol file:13078-13-2.mol

Synonyms:178928-62-6;1-(3-methylphenyl)piperazine hydrochloride;1-(3-methylphenyl)piperazine;hydrochloride;1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE;N-(3-Methylphenyl)piperazine hydrochloride;NSC-71662;NSC-150848;SCHEMBL6965723;4V85S2L7B9;NSC71662;NSC150848;AKOS025149808;Piperazine, 1-(3-methylphenyl)-, hydrochloride;Piperazine, 1-(3-methylphenyl)-, hydrochloride (1:1);PIPERAZINE, 1-(3-METHYLPHENYL)-, MONOHYDROCHLORIDE

Suppliers and Price of 1-(3-Methylphenyl)piperazine dihydrochloride hydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(m-Tolyl)piperazineDihydrochloride
50mg
$ 45.00

TCI Chemical
N-(m-Tolyl)piperazine Dihydrochloride >96.0%(T)
10g
$ 198.00

Chem-Impex
N-(m-Tolyl)piperazinedihydrochloride,≥96%(Assaybytitration) ≥96%(Assaybytitration)
10G
$ 224.18

American Custom Chemicals Corporation
1-(M-TOLYL)PIPERAZINE DIHYDROCHLORIDE 95.00%
250G
$ 5075.15

American Custom Chemicals Corporation
1-(M-TOLYL)PIPERAZINE DIHYDROCHLORIDE 95.00%
100G
$ 2797.79

AK Scientific
N-(m-Tolyl)piperazine Dihydrochloride
10g
$ 334.00

Total 17 raw suppliers

Chemical Property of 1-(3-Methylphenyl)piperazine dihydrochloride hydrate

Chemical Property:

Vapor Pressure:0.000299mmHg at 25°C
Melting Point:195-202 °C
Boiling Point:321.4°Cat760mmHg
Flash Point:154°C
PSA：15.27000
Density:g/cm³
LogP:3.40240
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:212.1080262
Heavy Atom Count:14
Complexity:152

Purity/Quality:

98% ^*data from raw suppliers

1-(m-Tolyl)piperazineDihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 36/37/38-24-22
Safety Statements: 45-36/37/39-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC=C1)N2CCNCC2.Cl

Technology Process of 1-(3-Methylphenyl)piperazine dihydrochloride hydrate

There total 3 articles about 1-(3-Methylphenyl)piperazine dihydrochloride hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 108-44-1
1-amino-3-methylbenzene

: 13078-13-2,178928-62-6
1-(m-tolyl)piperazine hydrochloride

Guidance literature:: bis-(2-chloroethyl)amine hydrochloride; 1-amino-3-methylbenzene; In butan-1-ol; for 24h; Reflux;

With potassium carbonate; In butan-1-ol; for 48h; Reflux;
DOI:10.1111/cbdd.13324

Reference yield:

: 1121596-67-5
tert-butyl 4-(m-tolyl)piperazine-1-carboxylate

: 13078-13-2,178928-62-6
1-(m-tolyl)piperazine hydrochloride

Guidance literature:: With hydrogenchloride; water monomer; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2022.116726

Reference yield:

: 591-17-3
meta-bromotoluene

: 13078-13-2,178928-62-6
1-(m-tolyl)piperazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; dicyclohexyl(2’,4’,6’-triisopropyl-[ 1,1’-bi-phenyl]-2-yl)phosphane; potassium-t-butoxide / 1,4-dioxane / 10 h / 90 °C

2: water monomer; hydrogenchloride / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; potassium-t-butoxide; water monomer; palladium diacetate; dicyclohexyl(2’,4’,6’-triisopropyl-[ 1,1’-bi-phenyl]-2-yl)phosphane; In 1,4-dioxane; ethyl acetate;
DOI:10.1016/j.bmc.2022.116726