Pyrrolo[1,2-a]pyrazine-6-acetic acid, 3-ethyloctahydro-1,4-dioxo-2-(phenylmethyl)-, ethyl ester

Base Information

• Chemical Name: Pyrrolo[1,2-a]pyrazine-6-acetic acid, 3-ethyloctahydro-1,4-dioxo-2-(phenylmethyl)-, ethyl ester
• CAS No.: 53301-20-5
• Molecular Formula: C₂₀H₂₆N₂O₄
• Molecular Weight: 358.437
• Mol file: 53301-20-5.mol

Synonyms:

Chemical Property of Pyrrolo[1,2-a]pyrazine-6-acetic acid, 3-ethyloctahydro-1,4-dioxo-2-(phenylmethyl)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrrolo[1,2-a]pyrazine-6-acetic acid, 3-ethyloctahydro-1,4-dioxo-2-(phenylmethyl)-, ethyl ester

There total 6 articles about Pyrrolo[1,2-a]pyrazine-6-acetic acid, 3-ethyloctahydro-1,4-dioxo-2-(phenylmethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

ethanol (64-17-5) + 2-Benzyl-6-(2-diazo-acetyl)-3-ethyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (92955-04-9) → estere etilico dell'acido 2-benzil-3-etilottaidro-1,4-diossopirrolo<1,2-a>pirazin-6-acetico (53301-20-5)

Guidance literature:

With silver benzoate; triethylamine; for 2h; Heating;

Reference yield:

1-(2-bromobutirril)-2-benzilcarbamil-5-etossicarbonilpirrolidina (53301-24-9) → estere etilico dell'acido 2-benzil-3-etilottaidro-1,4-diossopirrolo<1,2-a>pirazin-6-acetico (53301-20-5)

Guidance literature:

Multi-step reaction with 5 steps

1: Na / liquid ammonia / -40 °C

2: 1N NaCO₃ / H₂O; ethanol / 2 h / Ambient temperature

3: thionyl chloride / CHCl₃; dimethylformamide / Ambient temperature

4: diethyl ether; CH₂Cl₂ / cooling

5: 40 percent / triethylamine, silver benzoate / 2 h / Heating

With thionyl chloride; silver benzoate; sodium; triethylamine; In diethyl ether; ethanol; dichloromethane; chloroform; ammonia; water; N,N-dimethyl-formamide;

Reference yield:

2-benzilcarbamil-5-etossicarrbonilpirrolidina (52840-77-4) → estere etilico dell'acido 2-benzil-3-etilottaidro-1,4-diossopirrolo<1,2-a>pirazin-6-acetico (53301-20-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 59 percent / triethylamine / diethyl ether / room temp., 1 h then reflux, 1 h

2: Na / liquid ammonia / -40 °C

3: 1N NaCO₃ / H₂O; ethanol / 2 h / Ambient temperature

4: thionyl chloride / CHCl₃; dimethylformamide / Ambient temperature

5: diethyl ether; CH₂Cl₂ / cooling

6: 40 percent / triethylamine, silver benzoate / 2 h / Heating

With thionyl chloride; silver benzoate; sodium; triethylamine; In diethyl ether; ethanol; dichloromethane; chloroform; ammonia; water; N,N-dimethyl-formamide;

upstream raw materials:

ethanol

2-Benzyl-6-(2-diazo-acetyl)-3-ethyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

1-(2-bromobutirril)-2-benzilcarbamil-5-etossicarbonilpirrolidina

2-benzilcarbamil-5-etossicarrbonilpirrolidina

Downstream raw materials:

(2-benzyl-3-ethyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-6-yl)-acetic acid