Technology Process of Cyclopentaneoctanoic acid,
2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,5-dihydroxy-, methyl
ester, (1R,2R,3S,5R)-
There total 8 articles about Cyclopentaneoctanoic acid,
2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-3,5-dihydroxy-, methyl
ester, (1R,2R,3S,5R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 98 percent / K2CO3 / acetonitrile / 48 h / Heating
2.1: KHMDS / tetrahydrofuran; toluene / -80 - -40 °C
2.2: 70 percent / tetrahydrofuran; toluene / 2 h / -80 - 20 °C
3.1: 98 percent / hydrogen / Pd/C / methanol / 7 h / 3620.04 Torr
With
hydrogen; potassium hexamethylsilazane; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; toluene; acetonitrile;
2.2: Wittig reaction;
DOI:10.1021/jo035638i
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 61 percent / triphenylphosphine; iodine; imidazole / CH2Cl2 / -10 - 20 °C
2.1: 98 percent / K2CO3 / acetonitrile / 48 h / Heating
3.1: KHMDS / tetrahydrofuran; toluene / -80 - -40 °C
3.2: 70 percent / tetrahydrofuran; toluene / 2 h / -80 - 20 °C
4.1: 98 percent / hydrogen / Pd/C / methanol / 7 h / 3620.04 Torr
With
1H-imidazole; hydrogen; iodine; potassium hexamethylsilazane; potassium carbonate; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
3.2: Wittig reaction;
DOI:10.1021/jo035638i