6-amino-2-[[2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]hexanoic acid

Base Information

Chemical Name:6-amino-2-[[2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]hexanoic acid
CAS No.:97878-35-8
Molecular Formula:C₁₈H₂₅N₃O₅
Molecular Weight:363.414
Hs Code.:
Mol file:97878-35-8.mol

Synonyms:Abutapril;1H-1-Benzazepine-1-acetic acid, 3-[(5-amino-1-carboxypentyl)amino]-2,3,4,5-tetrahydro-2-oxo-, [S-(R*,R*)]-;6-amino-2-[[1-(carboxymethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]amino]hexanoic acid;Libenzapril;

Suppliers and Price of 6-amino-2-[[2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]hexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 5 raw suppliers

Chemical Property of 6-amino-2-[[2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]hexanoic acid

Chemical Property:

Vapor Pressure:3.7E-20mmHg at 25°C
Boiling Point:692.9°Cat760mmHg
Flash Point:372.9°C
PSA：132.96000
Density:1.33g/cm³
LogP:1.74700

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-amino-2-[[2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]hexanoic acid

There total 6 articles about 6-amino-2-[[2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 95384-35-3
3-[(5-benzyloxycarbonylamino-1-carboxy)-pentyl-(1S)-amino]-1-carboxymethyl-2,3,4,5-tetrahydro-1H-[1]-(3S)-benzazepin-2-one

: 97878-35-8
3(S)-<<(1S)-5-amino-1-carboxypentyl>amino>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-ethanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; for 40.5h; under 2280 Torr; Ambient temperature;
DOI:10.1021/jm00149a010

Reference yield:

: 24498-31-5
(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate

: 97878-35-8
3(S)-<<(1S)-5-amino-1-carboxypentyl>amino>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-ethanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: di-n-butyltin dichloride / CHCl₃ / 4.5 h / Heating

2: acetic acid, NaBH₃CN / methanol / Ambient temperature

3: 1N aq. NaOH / methanol / 19 h / Ambient temperature

4: 86 percent / H₂ / 10percent Pd/C / ethanol; H₂O / 40.5 h / 2280 Torr / Ambient temperature

With sodium hydroxide; dibutyltin chloride; hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In methanol; ethanol; chloroform; water;
DOI:10.1021/jm00149a010

Reference yield:

: 94793-89-2
3-(S)-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one

: 97878-35-8
3(S)-<<(1S)-5-amino-1-carboxypentyl>amino>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-ethanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) acetic acid, tert-butyl nitrite, 2.) m-chloroperbenzoic acid / 1.) CHCl₃, reflux, 2.5 h, 2.) CHCl₃, RT, 45 min

2: di-n-butyltin dichloride / CHCl₃ / 4.5 h / Heating

3: acetic acid, NaBH₃CN / methanol / Ambient temperature

4: 1N aq. NaOH / methanol / 19 h / Ambient temperature

5: 86 percent / H₂ / 10percent Pd/C / ethanol; H₂O / 40.5 h / 2280 Torr / Ambient temperature

With sodium hydroxide; tert.-butylnitrite; dibutyltin chloride; hydrogen; sodium cyanoborohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; ethanol; chloroform; water;
DOI:10.1021/jm00149a010