(3R,4S)-3-methyl-N-phenylpiperidin-4-amine

Base Information

Chemical Name:(3R,4S)-3-methyl-N-phenylpiperidin-4-amine
CAS No.:53757-54-3
Molecular Formula:C12H18N2
Molecular Weight:190.288
Hs Code.:
DSSTox Substance ID:DTXSID50451684
Nikkaji Number:J696.036G
Wikidata:Q82271826
Mol file:53757-54-3.mol

Synonyms:53757-54-3;(3R,4S)-3-methyl-N-phenylpiperidin-4-amine;SCHEMBL8989444;cis-3-methyl-4-anilinopiperidine;DTXSID50451684;N-Phenyl-3beta-methylpiperidin-4beta-amine

Suppliers and Price of (3R,4S)-3-methyl-N-phenylpiperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (3R,4S)-3-methyl-N-phenylpiperidin-4-amine

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:190.146998583
Heavy Atom Count:14
Complexity:164

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CNCCC1NC2=CC=CC=C2
Isomeric SMILES:C[C@@H]1CNCC[C@@H]1NC2=CC=CC=C2

Technology Process of (3R,4S)-3-methyl-N-phenylpiperidin-4-amine

There total 9 articles about (3R,4S)-3-methyl-N-phenylpiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58329-00-3
1-benzyl-3-methyl-N-phenyl-4-piperidinamine

: 53757-54-3
(+/-)-cis-3-methyl-N-phenyl-4-piperidinamine

: 57444-99-2
trans-3-Methyl-N-phenyl-4-piperidineamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 60 ℃; for 6h; under 775.7 Torr;
DOI:10.1021/jm00018a026

Reference yield:

: 58329-00-3,79278-34-5,97220-05-8,130149-82-5,130149-85-8
(+/-)-cis-1-benzyl-3-methyl-N-phenylpiperidinamine

: 53757-54-3
(+/-)-cis-3-methyl-N-phenyl-4-piperidinamine

Guidance literature:: With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; for 120h; under 2068.6 Torr;
DOI:10.1021/jm00009a015

Reference yield:

: 34737-89-8
1-Benzyl-3-methyl-4-piperidon

: 53757-54-3
(+/-)-cis-3-methyl-N-phenyl-4-piperidinamine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) toluene, EtOH, 2.) toluene, EtOH

2: HCl, H₂ / Pd(OH)2/C / methanol / 120 h / 2068.6 Torr

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium dihydroxide; In methanol;
DOI:10.1021/jm00009a015