(6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine

Base Information

Chemical Name:(6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine
CAS No.:537705-05-8
Molecular Formula:C21H17IN4O
Molecular Weight:468.297
Hs Code.:
DSSTox Substance ID:DTXSID40461111
Wikidata:Q82285357
Mol file:537705-05-8.mol

Synonyms:537705-05-8;(6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine;6-iodo-N-[3-methyl-4-(6-methylpyridin-3-yl)oxyphenyl]quinazolin-4-amine;6-Iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine;6-IODO-N-{3-METHYL-4-[(6-METHYLPYRIDIN-3-YL)OXY]PHENYL}QUINAZOLIN-4-AMINE;SCHEMBL2702250;DTXSID40461111;HZMVPCBYZKYRMS-UHFFFAOYSA-N;N-(4-(6-methylpyridin-3-yloxy)-3-methylphenyl)-6-iodoquinazolin-4-amine

Suppliers and Price of (6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of (6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine

Chemical Property:

Boiling Point:553.8±50.0 °C(Predicted)
PKA:5.40±0.50(Predicted)
PSA：59.93000
Density:1.590±0.06 g/cm3(Predicted)
LogP:5.85510
XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:468.04471
Heavy Atom Count:27
Complexity:481

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)I)C

Technology Process of (6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine

There total 8 articles about (6-Iodo-quinazolin-4-yl)-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 537705-06-9
3-(2-methyl-4-aminophenoxy)-6-methylpyridine

: 98556-31-1
4-chloro-6-iodoquinazoline

: 537705-05-8
6-iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine

Guidance literature:: In tetrahydrofuran; at 56 ℃; for 2.66667h;

Reference yield: 92.8%

: 537705-05-8
6-iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 2h;

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 537705-05-8
6-iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 3102.97 Torr

3: isopropyl alcohol / 12 h / Reflux

With hydrogen; caesium carbonate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;