Phosphinous acid, diphenyl-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

Base Information

• Chemical Name: Phosphinous acid, diphenyl-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
• CAS No.: 53772-43-3
• Molecular Formula: C15H11F6OP
• Molecular Weight: 352.216
• DSSTox Substance ID: DTXSID30518441
• Wikidata: Q82381131
• Mol file: 53772-43-3.mol

Synonyms:53772-43-3;Phosphinous acid, diphenyl-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;DTXSID30518441;1,1,1,3,3,3-Hexafluoropropan-2-yl diphenylphosphinite

Chemical Property of Phosphinous acid, diphenyl-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

Chemical Property:

• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 352.04517094
• Heavy Atom Count: 23
• Complexity: 326

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)OC(C(F)(F)F)C(F)(F)F

Technology Process of Phosphinous acid, diphenyl-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

There total 3 articles about Phosphinous acid, diphenyl-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

chloro-diphenylphosphine (1079-66-9,74391-44-9) + sodium 1-trifluoromethyl-2,2,2-trifluoroethoxide (6919-74-0) → 1,1,1,3,3,3-Hexafluoro-2-propyl Diphenylphosphinite (53772-43-3)

Guidance literature:

In dichloromethane; at 60 ℃; for 19h; Inert atmosphere; Glovebox; Schlenk technique; Cooling with ice;

DOI:10.1002/chem.201804805

Reference yield: 65.0%

1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 1,1,1,3,3,3-Hexafluoro-2-propyl Diphenylphosphinite (53772-43-3)

Guidance literature:

With triethylamine; In diethyl ether; 1) -40 degC to room temp., 2) room temp., 1h;

DOI:10.1021/jo00161a008

Reference yield:

→ 1,1,1,3,3,3-Hexafluoro-2-propyl Diphenylphosphinite (53772-43-3)

Guidance literature:

Diphenylchlorphosphin 15, 1,1,1,3,3,3-Hexafluorisopropanol 16;

upstream raw materials:

1,1,1,3',3',3'-hexafluoro-propanol

chloro-diphenylphosphine

sodium 1-trifluoromethyl-2,2,2-trifluoroethoxide

Downstream raw materials:

Diphenyltris(1,1,1,3,3,3-hexafluoro-2-propoxy)phosphorane

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