6-Bromo-2-hydroxy-1-naphthaldehyde

Base Information

• Chemical Name: 6-Bromo-2-hydroxy-1-naphthaldehyde
• CAS No.: 53815-56-8
• Molecular Formula: C11H7BrO2
• Molecular Weight: 251.079
• European Community (EC) Number: 850-629-7
• Nikkaji Number: J30.384D
• ChEMBL ID: CHEMBL3665103
• Mol file: 53815-56-8.mol

Synonyms:6-bromo-2-hydroxy-1-naphthaldehyde;53815-56-8;6-bromo-2-hydroxynaphthalene-1-carbaldehyde;MFCD01063097;6-Bromo-2-hydroxy-naphthalene-1-carbaldehyde;SCHEMBL1414921;CHEMBL3665103;BDBM111428;AKOS001609443;CS-0128651;FT-0753319;W11248;SR-01000079101;US8614253, 42-3;SR-01000079101-1;F0722-1799

Chemical Property of 6-Bromo-2-hydroxy-1-naphthaldehyde

Chemical Property:

• PSA: 37.30000
• LogP: 3.12040
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 249.96294
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

99%+, ^*data from raw suppliers

6-Bromo-2-hydroxy-1-naphthaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=C2C=O)O)C=C1Br

Technology Process of 6-Bromo-2-hydroxy-1-naphthaldehyde

There total 13 articles about 6-Bromo-2-hydroxy-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-bromo-naphthalen-2-ol (15231-91-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 6-Bromo-2-hydroxy-1-naphthaldehyde (53815-56-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 5 ℃; for 2h;

Reference yield: 89.3%

6-bromo-1-({[(6-bromo-2-hydroxynaphthalen-1-yl)-methyl]imino}methyl)naphthalen-2-ol → 6-Bromo-2-hydroxy-1-naphthaldehyde (53815-56-8)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 2.5h; Reflux;

DOI:10.1002/ardp.201700097

Reference yield: 85.0%

6-bromo-1-(pyrrolidin-1-ylmethyl)naphthalen-2-ol (727708-53-4) → 6-Bromo-2-hydroxy-1-naphthaldehyde (53815-56-8)

Guidance literature:

With tert.-butylhydroperoxide; water; sodium dodecyl-sulfate; copper(II) acetate monohydrate; at 120 ℃; for 3.5h;

DOI:10.1039/c6ra04567g

upstream raw materials:

6-bromo-naphthalen-2-ol

formaldehyd

2-hydroxynaphthalene-1-carbaldehyde

1,1-dichloromethyl-methyl ether

Downstream raw materials:

4-(5-formyl-6-hydroxynaphthalen-2-yl)-N,N-dimethylbenzamide

6-bromo-2-methoxynaphthalene-1-carbaldehyde

Refernces

• 1、 Luo, Na,Fang, Xiaoyu,Su, Mingbo,Zhang, Xinwen,Li, Dan,Li, Honglin,Li, Shiliang,Zhao, Zhenjiang. "Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors". supporting information. p. 115 - 120. Retrieved 2020/12/28.
• 2、 -. "Sulfur-containing heterocyclic compound and application thereof as derivative of DPP4 inhibitor". Paragraph 0072-0075; 0079-0081. . Retrieved 2019/11/12.