1H-Indole-1-carboxylic acid, 3-[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-oxo-3-[(2-phenyl ethyl)amino]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 3-[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-oxo-3-[(2-phenyl ethyl)amino]propyl]-, 1,1-dimethylethyl ester
CAS No.:540483-62-3
Molecular Formula:C39H39N3O5
Molecular Weight:629.756
Hs Code.:

1H-Indole-1-carboxylic acid,
3-[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-oxo-3-[(2-phenyl
ethyl)amino]propyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1H-Indole-1-carboxylic acid, 3-[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-oxo-3-[(2-phenyl ethyl)amino]propyl]-, 1,1-dimethylethyl ester

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Technology Process of 1H-Indole-1-carboxylic acid, 3-[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-oxo-3-[(2-phenyl ethyl)amino]propyl]-, 1,1-dimethylethyl ester

There total 1 articles about 1H-Indole-1-carboxylic acid, 3-[(2R)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-oxo-3-[(2-phenyl ethyl)amino]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 64-04-0
phenethylamine

: 163619-04-3
1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan

: 540483-62-3
N₁-phenethyl-(2R)-2-(9H-fluoren-9-ylmethoxy)-carboxamido-3-[1-(tert-butoxycarbonyl)-3-indolyl]-propanamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1h;
DOI:10.1021/jm0210921

Reference yield: 97.0%

: 540483-62-3
N₁-phenethyl-(2R)-2-(9H-fluoren-9-ylmethoxy)-carboxamido-3-[1-(tert-butoxycarbonyl)-3-indolyl]-propanamide

: 540483-63-4
tert-butyl-3-{(2R)-2-amino-2-[1-(2-phenylethyl)carbamoyl]ethyl}-1H-1-indolecarboxylate

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jm0210921

Reference yield:

: 540483-62-3
N₁-phenethyl-(2R)-2-(9H-fluoren-9-ylmethoxy)-carboxamido-3-[1-(tert-butoxycarbonyl)-3-indolyl]-propanamide

: N₁-(2-phenylethyl)-(2R)-2-{[N'-(2-furylmethyl)hydrazino]carboxamido}-3-(1H-3-indolyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / piperidine / dimethylformamide / 0.5 h / 20 °C

2: DMAP / CH₂Cl₂ / 20 °C

3: 65.1 mg / triisopropylsilane; TFA / CH₂Cl₂ / 0.5 h

With piperidine; dmap; chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0210921