Carbamic acid, [[1-[4-[[[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol -5-yl]carbonyl]amino]-3-fluorophenyl]-1H-imidazol-2-yl]methyl]methyl-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [[1-[4-[[[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol -5-yl]carbonyl]amino]-3-fluorophenyl]-1H-imidazol-2-yl]methyl]methyl-, phenylmethyl ester
CAS No.:540510-46-1
Molecular Formula:C31H24F4N8O4
Molecular Weight:648.576
Hs Code.:

Carbamic acid,
[[1-[4-[[[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol
-5-yl]carbonyl]amino]-3-fluorophenyl]-1H-imidazol-2-yl]methyl]methyl-,
phenylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [[1-[4-[[[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol -5-yl]carbonyl]amino]-3-fluorophenyl]-1H-imidazol-2-yl]methyl]methyl-, phenylmethyl ester

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Technology Process of Carbamic acid, [[1-[4-[[[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol -5-yl]carbonyl]amino]-3-fluorophenyl]-1H-imidazol-2-yl]methyl]methyl-, phenylmethyl ester

There total 11 articles about Carbamic acid, [[1-[4-[[[1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol -5-yl]carbonyl]amino]-3-fluorophenyl]-1H-imidazol-2-yl]methyl]methyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540510-45-0
benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

: 540510-46-1
[1-(4-{[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-3-fluoro-phenyl)-1H-imidazol-2-ylmethyl]-methyl-carbamic acid benzyl ester

Guidance literature:: With acetoxyhydroxamic acid; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm0497949

Reference yield:

: 473927-72-9
1-(1H-imidazol-2-yl)-N-methylmethanamine

: 540510-46-1
[1-(4-{[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-3-fluoro-phenyl)-1H-imidazol-2-ylmethyl]-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂; tetrahydrofuran / 1 h / 20 °C

1.2: TFA / ethyl acetate / 0.5 h / Heating

2.1: 67 percent / K₂CO₃; CuI / dimethylsulfoxide / 12 h / 120 °C

3.1: 52 percent / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: acetoxyhydroxamic acid; aq. K₂CO₃ / dimethylformamide / 12 h / 20 °C

With dmap; copper(l) iodide; acetoxyhydroxamic acid; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Ullmann coupling;
DOI:10.1021/jm0497949

Reference yield:

: 473927-49-0
benzyl 1H-imidazol-2-yl-methyl-(methyl)carbamate

: 540510-46-1
[1-(4-{[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-3-fluoro-phenyl)-1H-imidazol-2-ylmethyl]-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / K₂CO₃; CuI / dimethylsulfoxide / 12 h / 120 °C

2: 52 percent / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

3: acetoxyhydroxamic acid; aq. K₂CO₃ / dimethylformamide / 12 h / 20 °C

With dmap; copper(l) iodide; acetoxyhydroxamic acid; potassium carbonate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Ullmann coupling;
DOI:10.1021/jm0497949