Methanone, (2-amino-4-methyl-3-thienyl)(4-chlorophenyl)-

Base Information

Chemical Name:Methanone, (2-amino-4-methyl-3-thienyl)(4-chlorophenyl)-
CAS No.:54359-54-5
Molecular Formula:C12H10ClNOS
Molecular Weight:251.737
Hs Code.:

Synonyms:(2-amino-4-methylthiophen-3-yl)(4-chlorophenyl)methanone;(2-amino-4-methyl-thiophen-3-yl)-(4-chloro-phenyl)-methanone;

Suppliers and Price of Methanone, (2-amino-4-methyl-3-thienyl)(4-chlorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Methanone, (2-amino-4-methyl-3-thienyl)(4-chlorophenyl)-

Chemical Property:

Melting Point:148 - 150 °C
PSA：71.33000
LogP:4.10430

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanone, (2-amino-4-methyl-3-thienyl)(4-chlorophenyl)-

There total 3 articles about Methanone, (2-amino-4-methyl-3-thienyl)(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 55704-78-4,146511-93-5
2,5-dihydroxy-2,5-dimethyl-1,4-dithiane

: 4640-66-8
p-chlorobenzoylacetonitrile

: 54359-54-5
(2-amino-4-methyl-thiophen-3-yl)-(4-chloro-phenyl)-methanone

Guidance literature:: With triethylamine; In ethanol; for 2.16667h; Cooling with ice; Reflux; Inert atmosphere;
DOI:10.1021/jm800586p

Reference yield:

: 74-11-3
para-chlorobenzoic acid

: 54359-54-5
(2-amino-4-methyl-thiophen-3-yl)-(4-chloro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 12 h / 0 °C / Heating; Large scale

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: diethylamine / ethanol / 16 h / 50 °C

With sulfuric acid; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

Reference yield:

: 1126-46-1
Methyl 4-chlorobenzoate

: 54359-54-5
(2-amino-4-methyl-thiophen-3-yl)-(4-chloro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: diethylamine / ethanol / 16 h / 50 °C

With diethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol;