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4-Chlorobenzoic acid
Cas No: 74-11-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 4-Chlorobenzoic Acid supplier in China
Cas No: 74-11-3
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
4-Chlorobenzoic acid
Cas No: 74-11-3
USD $ 12.0-12.0 / Gram 10 Gram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
High Quality Oled CAS 74-11-3 Benzoic acid, 4-chloro-
Cas No: 74-11-3
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply 4-chlorobenzoic acid
Cas No: 74-11-3
No Data 1 1 Ality Chemical Corporation Contact Supplier
4-chlorobenzoate
Cas No: 74-11-3
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
4-Chlorobenzoic Acid
Cas No: 74-11-3
No Data 1 Metric Ton 1 million Metric Ton/Year COLORCOM LTD. Contact Supplier
4-chlorobenzoic Acid CAS NO.74-11-3
Cas No: 74-11-3
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
4-Chlorobenzoic acid CAS: 74-11-3
Cas No: 74-11-3
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 2500 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
TIANFUCHEM--74-11-3-- 4-Chlorobenzoic acid factory price
Cas No: 74-11-3
USD $ 2000.0-2000.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

74-11-3 Usage

Chemical Properties

white to light yellow crystal powder. Soluble in methanol, anhydrous ethanol and ether, very slightly soluble in water, toluene and 95% ethanol.

Uses

4-Chlorobenzoic acid is a benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioas says. It is used as a preservative.P-chlorobenzoic acid is the intermediate of fungicide dimethomorph, rodenticide Warfarin, Coumatetralyl and insecticide flumethrin, and also the intermediate of dye and medicine.

Uses

4-Chlorobenzoic acid can be used:As a ligand to synthesize luminescent lanthanide complexes for bio-labeling or fiber communication applications.To prepare organotin(IV) chlorobenzoates exhibiting anticorrosion properties.As a ligand to synthesize di-n-butyl(4-chlorobenzoxy)(4-chlorobenzohydroxamato)tin(IV).

Preparation

4-Chlorobenzoic acid is obtained by oxidation of p-chlorotoluene: add potassium permanganate solution to the mixture of p-chlorotoluene and water in stages. The reaction is refluxed under stirring for 5-6h, then acidified with hydrochloric acid to pH 2, filtered to obtain the crude product, and recrystallized with ethanol to obtain the finished product.

Definition

ChEBI: 4-chlorobenzoic acid is a monochlorobenzoic acid carrying a chloro substituent at position 4. It has a role as a bacterial xenobiotic metabolite. It derives from a benzoic acid. It is a conjugate acid of a 4-chlorobenzoate.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 135, 1943Synthetic Communications, 25, p. 3695, 1995 DOI: 10.1080/00397919508015507Tetrahedron Letters, 22, p. 1013, 1981 DOI: 10.1016/S0040-4039(01)82853-7

General Description

Triclinic crystals or light fluffy white powder.4-Chlorobenzoic acid is a degradation product of indomethacin. It is degraded by Acinetobacter sp. strain ST-1 and causes its dehalogenation to yield 4-hydroxybenzoic acid under both aerobic and anaerobic conditions.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Chlorobenzoic acid is incompatible with strong oxidizing agents and strong bases.

Fire Hazard

Flash point data for 4-Chlorobenzoic acid are not available; however, 4-Chlorobenzoic acid is probably combustible.

Purification Methods

Purify it as for m-chlorobenzoic acid. It has also been crystallised from hot water, and from EtOH. [Beilstein 9 IV 973.]
InChI:InChI=1/C7H5ClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)/p-1

74-11-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A15135)  4-Chlorobenzoic acid, 98+%    74-11-3 250g 464.0CNY Detail
Alfa Aesar (A15135)  4-Chlorobenzoic acid, 98+%    74-11-3 1000g 1389.0CNY Detail
Alfa Aesar (A15135)  4-Chlorobenzoic acid, 98+%    74-11-3 5000g 5254.0CNY Detail
Supelco (506885)  4-Chlorobenzoicacid  analytical standard 74-11-3 000000000000506885 255.06CNY Detail
Sigma-Aldrich (Y0000811)  AcemetacinimpurityA  European Pharmacopoeia (EP) Reference Standard 74-11-3 Y0000811 1,880.19CNY Detail
USP (1112423)  IndomethacinRelatedCompoundB  United States Pharmacopeia (USP) Reference Standard 74-11-3 1112423-25MG 14,500.98CNY Detail

74-11-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chlorobenzoic acid

1.2 Other means of identification

Product number -
Other names 4 CHLOROBENZOIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74-11-3 SDS

74-11-3Synthetic route

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With sodium perborate In acetic acid for 1.5h; steam bath;100%
With hydrogen bromide; oxygen In acetonitrile at 20℃; for 5h; UV-irradiation;100%
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;99%
benzyl p-chlorobenzoate
67483-73-2

benzyl p-chlorobenzoate

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With hydrogen In ethyl acetate at 60℃; for 24h; Reagent/catalyst;100%
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.0833333h; chemoselective reaction;87%
With ammonium cerium(IV) nitrate In water; acetonitrile for 6h; Mechanism; Heating; other esters react in the same way;65%
allyl 4-chlorobenzoate
15784-28-8

allyl 4-chlorobenzoate

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With formic acid; triethylamine In acetonitrile at 80℃; for 1h; Inert atmosphere;100%
With toluene-4-sulfonic acid for 0.0666667h; microwave irradiation;86%
With iodine; dimethyl sulfoxide for 0.2h; Heating;76%
With ammonium cerium(IV) nitrate In water; acetonitrile for 6h; Mechanism; Heating; other esters react in the same way;74%
para-Chlorobenzyl alcohol
873-76-7

para-Chlorobenzyl alcohol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With bromine; oxygen In acetonitrile for 10h; Irradiation;100%
With periodic acid; tripropylammonium fluorochromate (VI) In acetonitrile at 0℃;99%
With silica-supported Jones reagent In dichloromethane for 0.035h;99.4%
4-chlorobenzoic anhydride
790-41-0

4-chlorobenzoic anhydride

A

para-Chlorobenzyl alcohol
873-76-7

para-Chlorobenzyl alcohol

B

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate In tetrahydrofuran for 1h; Ambient temperature;A 94%
B 100%
4-chloro-N,N-diisopropylbenzamide
79606-45-4

4-chloro-N,N-diisopropylbenzamide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; zinc(II) chloride at 160℃; for 72h;100%
para-chlorotoluene
106-43-4

para-chlorotoluene

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With Oxone; potassium bromide In dichloromethane; water at 20℃; for 24h; visible light irradiation;99%
With ruthenium trichloride; sodium hypochlorite; tetrabutylammomium bromide In 1,2-dichloro-ethane at 25℃; for 2h;98%
With ruthenium trichloride; sodium hypochlorite; tetrabutylammomium bromide In 1,2-dichloro-ethane at 25℃; for 2h; Rate constant; Mechanism; pH 9: other methylbenzenes; var. concentration of aq. NaOCl, ruthenium and tetrabutylammonium bromide;98%
Methyl 4-chlorobenzoate
1126-46-1

Methyl 4-chlorobenzoate

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With iodine; aluminium In acetonitrile at 80℃; for 18h;99%
With potassium hydroxide In toluene at 150℃; for 0.166667h; microwave irradiation;94%
With sodium hydroxide In N,N-dimethyl-formamide for 0.5h; Ambient temperature;93%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With amphiphilic resin-supported phosphine-palladium; water; potassium carbonate at 25℃; under 760 Torr; for 12h; hydroxycarbonylation;99%
With dichloro bis(acetonitrile) palladium(II); potassium hydroxide; sodium dodecyl-sulfate In water; butan-1-ol at 70℃; under 760 Torr; for 4h;94%
With potassium carbonate; palladium diacetate In water; N,N-dimethyl-formamide at 25℃; under 760 Torr; for 2h;92%
cobalt (II) acetate·4 H2O

cobalt (II) acetate·4 H2O

para-chlorotoluene
106-43-4

para-chlorotoluene

1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione
143435-52-3

1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With acetic acid99%
4-chlorobenzyl azide
27032-10-6

4-chlorobenzyl azide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With tert.-butylhydroperoxide; vanadia In water at 100℃; for 6h;99%
1-chloro-4-{[(phenylmethyl)oxy]methyl}benzene
3395-72-0

1-chloro-4-{[(phenylmethyl)oxy]methyl}benzene

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With Oxone; potassium bromide In acetonitrile at 0 - 30℃; for 24.5h; Green chemistry;99%
2-(4-Chlorophenyl)ethanol
1875-88-3

2-(4-Chlorophenyl)ethanol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With oxygen; sodium t-butanolate In tetrahydrofuran at 20℃; under 750.075 Torr; for 17h; chemoselective reaction;99%
bromochlorobenzene
106-39-8

bromochlorobenzene

carbon monoxide
201230-82-2

carbon monoxide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With tetrabutylammomium bromide; dicobalt octacarbonyl In sodium hydroxide; benzene at 65℃; for 1h; Irradiation;98%
With sodium hydroxide; tetrabutylammomium bromide; dicobalt octacarbonyl In water; benzene at 65℃; under 760 Torr; for 1h; Irradiation;98%
ethyl 4-chlorobenzoate
7335-27-5

ethyl 4-chlorobenzoate

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
Stage #1: ethyl 4-chlorobenzoate With iron(III) chloride In tetrachloromethane at 85℃; for 24h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In tetrachloromethane Inert atmosphere;
98%
With potassium hydroxide In methanol at 35℃; for 0.333333h;89%
With ammonium cerium(IV) nitrate In water; acetonitrile for 6h; Mechanism; Heating; other esters react in the same way;58%
Stage #1: ethyl 4-chlorobenzoate With sodium hydroxide In water at 20℃;
Stage #2: With hydrogenchloride In water
With water; lithium hydroxide In tetrahydrofuran at 25℃; for 6h; Reagent/catalyst; Solvent;92 %Chromat.
p-chlorobenzoylmethanesulfonic acid
98554-12-2

p-chlorobenzoylmethanesulfonic acid

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With water; sodium hydroxide for 5h; Heating;98%
para-chloroacetophenone
99-91-2

para-chloroacetophenone

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With 1,10-Phenanthroline; oxygen; copper diacetate; potassium hydroxide In dimethyl sulfoxide at 130℃; under 3000.3 Torr; for 12h; Autoclave;97%
Stage #1: para-chloroacetophenone With tert.-butylhydroperoxide; sodium hydroxide; tungsten(VI) oxide In water at 80℃; for 8h;
Stage #2: With hydrogenchloride In water
94%
With copper(II) nitrate trihydrate; oxygen In acetonitrile at 120℃; under 4500.45 Torr; for 10h; Autoclave;93%
4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With t-butyl thionitrite; copper dichloride In acetonitrile at 25℃; for 0.0333333h;97%
Stage #1: 4-amino-benzoic acid With tert.-butylnitrite In acetonitrile at 20℃; Sandmeyer Reaction; Flow reactor;
Stage #2: With copper dichloride In ethylene glycol; acetonitrile at 82℃; Sandmeyer Reaction; Flow reactor;
50%
With hydrogenchloride; potassium nitrite; dimethyl sulfoxide; copper(l) chloride In water at 35℃; for 0.5h;77 % Chromat.
4-chloro-benzoic acid 3-methyl-but-2-enyl ester

4-chloro-benzoic acid 3-methyl-but-2-enyl ester

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With Montmorillonite K-10 clay; toluene for 0.333333h; Dealkylation; Microwave irradiation;97%
With toluene-4-sulfonic acid for 0.0666667h; microwave irradiation;84%
benzyl p-chlorobenzoate
67483-73-2

benzyl p-chlorobenzoate

toluene
108-88-3

toluene

A

1-methyl-3-(phenylmethyl)-benzene
620-47-3

1-methyl-3-(phenylmethyl)-benzene

B

1-methyl-4-(phenylmethyl)benzene
620-83-7

1-methyl-4-(phenylmethyl)benzene

C

2-benzyltoluene
713-36-0

2-benzyltoluene

D

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction;A n/a
B n/a
C n/a
D 97%
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With sodium hydroxide In water; tert-butyl alcohol at 70℃; Ni-anode, 16 mA/cm2;96%
4-chlorobenzyl bromide
622-95-7

4-chlorobenzyl bromide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With Oxone In water; acetonitrile for 9h; Reflux;96%
With sodium periodate; sulfuric acid In water at 95℃; for 12h;79%
With tert.-butylhydroperoxide In water at 80℃; for 12h; Green chemistry;
Multi-step reaction with 2 steps
1: silver(I) nitrite / diethyl ether / 5 h / 0 °C / Reflux
2: tetra-(n-butyl)ammonium iodide; zinc diacetate; water / 24 h / 80 °C
View Scheme
para-chlorotoluene
106-43-4

para-chlorotoluene

A

N-acetoxy-1,8-naphthalenedicarboximide

N-acetoxy-1,8-naphthalenedicarboximide

B

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With acetic acid In titaniumA n/a
B 96%
1-(p-chlorophenyl)ethyl alcohol
3391-10-4

1-(p-chlorophenyl)ethyl alcohol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With sodium nitrate; water; oxygen In dimethyl sulfoxide at 130℃; for 24h;96%
With 1,10-Phenanthroline; oxygen; copper diacetate; potassium hydroxide In dimethyl sulfoxide at 130℃; under 3000.3 Torr; for 12h; Autoclave;93%
With iron(III) chloride; cerium(III) chloride; tetrabutyl-ammonium chloride; oxygen In acetonitrile at 20℃; under 760.051 Torr; for 24h; Schlenk technique; Irradiation;90%
para-chlorotoluene
106-43-4

para-chlorotoluene

A

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

B

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; oxygen; 9-(2-mesityl)-10-methylacridinium perchlorate In acetonitrile at 4.84℃; for 12h; Irradiation;A 5%
B 95%
With N-hydroxyphthalimide; oxygen; cobalt(II) acetate In acetic acid at 25℃; under 760 Torr; for 20h;A 3%
B 67%
With sulfuric acid bei der elektrolytischen Oxydation;
para-dichlorobenzene
106-46-7

para-dichlorobenzene

carbon dioxide
124-38-9

carbon dioxide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With magnesium In tetrahydrofuran for 0.5h; Heating;95%
With Al-anode In N,N-dimethyl-formamide at 20℃; electrocarboxylation;78%
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 4h; Electrolysis;66%
Stage #1: para-dichlorobenzene With bis(cyclopentadienyl)titanium dichloride; butyl magnesium bromide In tetrahydrofuran at 40℃; for 6h; Inert atmosphere; Schlenk technique;
Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Schlenk technique;
44%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

A

para-Chlorobenzyl alcohol
873-76-7

para-Chlorobenzyl alcohol

B

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
Stage #1: 4-chlorobenzaldehyde With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry;
Stage #2: With hydrogenchloride In water Green chemistry;
A 95%
B 95%
With sodium hydroxide In water at 20℃; for 3.5h; Cannizzaro Reaction;A n/a
B 89%
With TEA; magnesium bromide In dichloromethane at 20℃; for 48h; Cannizzaro reaction;A 88%
B n/a
cinnamyl 4-chlorobenzoate

cinnamyl 4-chlorobenzoate

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With Montmorillonite K-10 clay; methoxybenzene for 0.333333h; Dealkylation; Microwave irradiation;95%
With methoxybenzene In toluene for 15h; Heating;5%
4-chlorophenyl trifluoromethanesulfonate
29540-84-9

4-chlorophenyl trifluoromethanesulfonate

molybdenum hexacarbonyl

molybdenum hexacarbonyl

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate at 150℃; for 0.333333h; microwave irradiation;95%
C16H25ClO2Si

C16H25ClO2Si

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With water; N,N-dimethyl-formamide at 70℃; for 1h; Green chemistry; chemoselective reaction;95%
methanol
67-56-1

methanol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Methyl 4-chlorobenzoate
1126-46-1

Methyl 4-chlorobenzoate

Conditions
ConditionsYield
With sulfuric acid for 4h; Reflux;100%
With sulfuric acid Fischer-Speier esterification method; Reflux;100%
With di(methoxycarbonyl)methylene tri-n-butylphosphorane In toluene at 70℃; for 24h;98%
para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;100%
With thionyl chloride for 2h; Reflux;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Reflux;100%
para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

para-Chlorobenzyl alcohol
873-76-7

para-Chlorobenzyl alcohol

Conditions
ConditionsYield
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Inert atmosphere;100%
With samarium diiodide; benzaldehyde; samarium(III) trifluoromethanesulfonate In tetrahydrofuran; methanol; water at 20℃; for 0.0166667h; Reduction;99%
With samarium diiodide; phosphoric acid In tetrahydrofuran for 0.000833333h; Ambient temperature;94%
benzyl alcohol
100-51-6

benzyl alcohol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

benzyl p-chlorobenzoate
67483-73-2

benzyl p-chlorobenzoate

Conditions
ConditionsYield
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride In acetonitrile for 1.5h; Heating;100%
Stage #1: para-chlorobenzoic acid With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In neat (no solvent) at 20℃; for 0.0166667h;
Stage #2: benzyl alcohol In neat (no solvent) at 20℃; for 0.216667h;
90%
Stage #1: para-chlorobenzoic acid With N-chlorobenzotriazole; triphenylphosphine In dichloromethane for 0.25h; Cooling;
Stage #2: benzyl alcohol With triethylamine In dichloromethane at 20℃; for 0.583333h;
85%
With 2-butyl-1,3-diphenyl-1,3,2-diazaphospholidine; 1,1'-azodicarbonyl-dipiperidine In 1,2-dichloro-ethane at 40℃; under 760.051 Torr; Mitsunobu Displacement;85%
para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
Stage #1: para-chlorobenzoic acid With palladium/alumina; hydrogen; potassium carbonate In water at 60℃;
Stage #2: With hydrogenchloride In water
100%
With hydrogen; triethylamine; palladium on activated charcoal In methanol at 20℃; for 6h;99%
With ammonium formate In water; isopropyl alcohol at 20℃; for 3h;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

moclobemide
71320-77-9

moclobemide

Conditions
ConditionsYield
With tetramethylorthosilicate In toluene at 110℃; for 1h; Inert atmosphere;100%
With zirconocene dichloride In toluene at 110℃; for 24h; Inert atmosphere; sealed tube;86%
With [((CH3)5Cp)2Zr(H2O)2OSO2C8F17]+[OSO2C8F17]-*THF In tetrahydrofuran at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature;85%
n-heptan1ol
111-70-6

n-heptan1ol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

heptyl 4-chlorobenzoate
97222-05-4

heptyl 4-chlorobenzoate

Conditions
ConditionsYield
With Candida antarctica lipase B immobilised in a macroporous DVB crosslinked polymer (Novozym 435) In cyclohexane at 80℃; for 24h; Enzymatic reaction;100%
propargyl bromide
106-96-7

propargyl bromide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

prop-2-yn-1-yl 4-chlorobenzoate
79318-18-6

prop-2-yn-1-yl 4-chlorobenzoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 5h;100%
ethanol
64-17-5

ethanol

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

ethyl 4-chlorobenzoate
7335-27-5

ethyl 4-chlorobenzoate

Conditions
ConditionsYield
With sulfuric acid for 0.666667h; Reflux;99.7%
With sulfuric acid for 5h; Reflux;93.4%
With sulfuric acid for 3h; Heating;87%
4-(diazomethyl)-7-methoxycoumarin
84471-16-9

4-(diazomethyl)-7-methoxycoumarin

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-Chloro-benzoic acid 7-methoxy-2-oxo-2H-chromen-4-ylmethyl ester
76196-61-7

4-Chloro-benzoic acid 7-methoxy-2-oxo-2H-chromen-4-ylmethyl ester

Conditions
ConditionsYield
In acetonitrile at 80℃; for 1h;99.7%
aniline
62-53-3

aniline

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-chlorobenzanilide
6833-15-4

4-chlorobenzanilide

Conditions
ConditionsYield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;99%
With nano sulfated-TiO2 at 115℃; under 760.051 Torr; for 4h; Neat (no solvent);98%
With triethylamine; Phenyl N-phenylphosphoramidochloridate In dichloromethane for 0.333333h; Ambient temperature;93%
para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-chlorobenzoic anhydride
790-41-0

4-chlorobenzoic anhydride

Conditions
ConditionsYield
With iodine; triethylamine; triphenylphosphine In dichloromethane at 0 - 20℃;99%
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; tributyl-amine In acetonitrile at 20℃; for 0.5h;97%
With thionyl chloride In dichloromethane at 22 - 25℃; for 1h;96.9%
benzylamine
100-46-9

benzylamine

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

N-benzyl-p-chlorobenzamide
7461-34-9

N-benzyl-p-chlorobenzamide

Conditions
ConditionsYield
With Bromotrichloromethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine In tetrahydrofuran at 60℃; for 6h; Inert atmosphere;99%
With borane-ammonia complex In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Reflux;99%
With nickel ferrite nanoparticle In neat (no solvent) for 0.166667h; Irradiation; Sealed tube;92%
thiophene
188290-36-0

thiophene

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

2-(4-chlorobenzoyl)thiophene
4153-45-1

2-(4-chlorobenzoyl)thiophene

Conditions
ConditionsYield
With pyridin-2-yl trifluoromethanesulfonate; trifluoroacetic acid for 4h; Heating;99%
With phosphoric acid; trifluoroacetic anhydride In water at 20℃; for 2h;87%
benzyl bromide
100-39-0

benzyl bromide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

benzyl p-chlorobenzoate
67483-73-2

benzyl p-chlorobenzoate

Conditions
ConditionsYield
With N(Et)4(1+)*(2-pyrrolidone-anion) In N,N-dimethyl-formamide for 1h; Ambient temperature;99%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-chloro-N-methoxy-N-methylbenzamide
122334-37-6

4-chloro-N-methoxy-N-methylbenzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20℃; for 0.5h;99%
Stage #1: para-chlorobenzoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0℃; for 0.5h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
99%
Stage #1: para-chlorobenzoic acid With triethylamine; trichloromethyl chloroformate In dichloromethane at 0℃;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 25℃; for 1h;
96%
N,0-dimethylhydroxylamine
1117-97-1

N,0-dimethylhydroxylamine

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-chloro-N-methoxy-N-methylbenzamide
122334-37-6

4-chloro-N-methoxy-N-methylbenzamide

Conditions
ConditionsYield
Stage #1: N,0-dimethylhydroxylamine; para-chlorobenzoic acid In toluene at 0℃; for 0.166667h;
Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;
99%
With 1,1'-carbonyldiimidazole
With triethylamine; 1,1'-carbonyldiimidazole
Boc-Apns-Dmt-NHtBu
159000-71-2

Boc-Apns-Dmt-NHtBu

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-({(4R)-4-[(tert-butylamino)carbonyl]-5,5-dimethyl-1,3-thiazolan-3-yl}carbonyl)-3-phenylpropyl 4-chlorobenzoate

(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-({(4R)-4-[(tert-butylamino)carbonyl]-5,5-dimethyl-1,3-thiazolan-3-yl}carbonyl)-3-phenylpropyl 4-chlorobenzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;99%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;
sodium cyanide
143-33-9

sodium cyanide

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

4-cyanobenzoic Acid
619-65-8

4-cyanobenzoic Acid

Conditions
ConditionsYield
With nickel dibromide In 1-methyl-pyrrolidin-2-one at 200℃; under 10343 Torr; for 0.166667h; microwave irradiation;99%
para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

phenylboronic acid
98-80-6

phenylboronic acid

biphenyl-4-carboxylic acid
92-92-2

biphenyl-4-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In water at 80℃; for 2h; Suzuki Coupling; Green chemistry;99%
With glucosamine-based dicyclohexylarylphosphine; sodium carbonate; palladium diacetate In ethanol; water; toluene at 80℃; Suzuki-Miyaura cross coupling reaction;97%
With sodium hydroxide; polyaniline-supported palladium In water at 80℃; for 4h; Suzuki coupling;97%
3-Carboxyphenylboronic acid
25487-66-5

3-Carboxyphenylboronic acid

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

biphenyl-3,4′-dicarboxylic acid
92152-01-7

biphenyl-3,4′-dicarboxylic acid

Conditions
ConditionsYield
With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; potassium carbonate In water at 50℃; for 8h; Suzuki-Miyaura coupling;99%

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