(1R,2S)-2-(2-Hydroxyethyl)cyclopent-3-en-1-ol

Base Information

• Chemical Name: (1R,2S)-2-(2-Hydroxyethyl)cyclopent-3-en-1-ol
• CAS No.: 54483-54-4
• Molecular Formula: C7H12O2
• Molecular Weight: 128.171
• DSSTox Substance ID: DTXSID50574423
• Nikkaji Number: J1.023.245G
• Wikidata: Q82463454
• Mol file: 54483-54-4.mol

Synonyms:54483-54-4;(1R,2S)-2-(2-Hydroxyethyl)cyclopent-3-en-1-ol;SCHEMBL11277140;DTXSID50574423;UPMJCBJKDZVWNI-RNFRBKRXSA-N;(-)-cis-2-(2'-Hydroxyethyl)-cyclopent-3-enol;(-)-cis-2-(2'-hydroxyethyl-)cyclopent-3-ene-ol

Chemical Property of (1R,2S)-2-(2-Hydroxyethyl)cyclopent-3-en-1-ol

Chemical Property:

• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.083729621
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C=CC(C1O)CCO
• Isomeric SMILES: C1C=C[C@@H]([C@@H]1O)CCO

Technology Process of (1R,2S)-2-(2-Hydroxyethyl)cyclopent-3-en-1-ol

There total 2 articles about (1R,2S)-2-(2-Hydroxyethyl)cyclopent-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one (34638-25-0,38110-77-9,43119-28-4,54483-22-6,26054-46-6) → (+)-2β-hydroxyethyl-3-cyclopenten-1β-ol (54483-54-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

DOI:10.1016/S0040-4020(98)00471-2 DOI:10.1016/S0040-4020(99)00424-X

Reference yield:

cis-(±)-2-oxabicyclo[3.3.0]oct-6-en-3-one (26054-46-6) → 1-hydroxy-2-(2-hydroxyethyl)cyclopent-3-ene (49826-08-6,54483-54-4,54483-55-5,75331-67-8)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/ja00447a057

Reference yield: 96.0%

1-hydroxy-2-(2-hydroxyethyl)cyclopent-3-ene (49826-08-6,54483-54-4,54483-55-5,75331-67-8) + trityl chloride (76-83-5) → dl-cis-2-(2-hydroxycyclopent-4-enyl)ethanol triphenylmethyl ether (112967-36-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1021/jm00163a038

upstream raw materials:

(1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one

cis-(±)-2-oxabicyclo[3.3.0]oct-6-en-3-one

Downstream raw materials:

(+)-2β-(2-trityloxy-ethyl)-3-cyclopenten-1β-ol

(1R,2S)-2-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-cyclopent-3-enol

(1S,2R)-benzoic acid 2-(2-hydroxycyclopent-4-enyl)ethyl ester

(1S,2S)-2-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-cyclopent-3-enylamine