13-Oxa-2,8,11-triazapentadecanoic acid, 7-(methoxycarbonyl)-14,14-dimethyl-12-oxo-, (2-chlorophenyl)methyl ester, (7R)-

Base Information

Chemical Name:13-Oxa-2,8,11-triazapentadecanoic acid, 7-(methoxycarbonyl)-14,14-dimethyl-12-oxo-, (2-chlorophenyl)methyl ester, (7R)-
CAS No.:548490-56-8
Molecular Formula:C22H34ClN3O6
Molecular Weight:471.981
Hs Code.:

Synonyms:

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Chemical Property of 13-Oxa-2,8,11-triazapentadecanoic acid, 7-(methoxycarbonyl)-14,14-dimethyl-12-oxo-, (2-chlorophenyl)methyl ester, (7R)-

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Technology Process of 13-Oxa-2,8,11-triazapentadecanoic acid, 7-(methoxycarbonyl)-14,14-dimethyl-12-oxo-, (2-chlorophenyl)methyl ester, (7R)-

There total 2 articles about 13-Oxa-2,8,11-triazapentadecanoic acid, 7-(methoxycarbonyl)-14,14-dimethyl-12-oxo-, (2-chlorophenyl)methyl ester, (7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 548490-58-0
(R)-2-Amino-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 548490-56-8
2-(2-tert-butoxycarbonylamino-ethylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

Guidance literature:: (R)-2-Amino-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester; N-(t-butoxycarbonyl)glycinal; In methanol; at 20 ℃; for 30h;

With sodium cyanoborohydride; acetic acid; In methanol; at 0 ℃; for 1h; Further stages.;
DOI:10.1002/ejoc.200390148

Reference yield:

: 57096-11-4
N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-D-lysine

: 548490-56-8
2-(2-tert-butoxycarbonylamino-ethylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / thionyl chloride / 24 h / 20 °C

2.1: methanol / 30 h / 20 °C

2.2: 64 percent / NaBH₃CN; acetic acid / methanol / 1 h / 0 °C

With thionyl chloride; In methanol;
DOI:10.1002/ejoc.200390148