548490-58-0Relevant academic research and scientific papers
Synthesis of new chiral PNAs bearing a dipeptide-mimic monomer with two lysine-derived stereogenic centres
Tedeschi, Tullia,Sforza, Stefano,Corradini, Roberto,Marchelli, Rosangela
, p. 8395 - 8399 (2007/10/03)
The synthesis of new chiral PNA analogues based on lysine is reported. In particular, l- and/or d-lysine-based PNA submonomers bearing two lysine side chains exactly spaced as in the dipeptide Lys-Lys were synthesized and incorporated in the middle of dec
Fast, solid-phase synthesis of chiral peptide nucleic acids with a high optical purity by a submonomeric strategy
Sforza, Stefano,Tedeschi, Tullia,Corradini, Roberto,Ciavardelli, Domenico,Dossena, Arnaldo,Marchelli, Rosangela
, p. 1056 - 1063 (2007/10/03)
The solid-phase synthesis of chiral peptide nucleic acids (PNAs) usually results in partial epimerization of the products, since the α-nitrogen atom of the amino acid is involved in an amidic bond. It is also time-consuming, since all the chiral monomers
